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The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders.

Author: BossChristoph, BrotschiChristine, GatfieldJohn, HeidmannBibia, RochCatherine, SchmidtGunther, SifferlenThierry, TreiberAlexander, WilliamsJodi T, von RaumerMarkus

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study describes the development of a new drug, daridorexant, which is a dual orexin receptor antagonist (DORA). Daridorexant is currently in phase 3 clinical trials for the treatment of insomnia disorders.
Paper Details　
Original Abstract of the Article :
Since its discovery in 1998, the orexin system has been of interest to the research community as a potential therapeutic target for the treatment of sleep/wake disorders, stress and anxiety disorders, addiction or eating disorders. It consists of two G protein-coupled receptors, the orexin 1 and ore...See full text at original site
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引用元：
https://doi.org/10.1002/cmdc.202000453

データ提供：米国国立医学図書館（NLM）

Targeting the Orexin System: A New Approach to Insomnia

Insomnia is a common and often frustrating sleep disorder. This study explores the potential of orexin receptor antagonists, specifically daridorexant, as a novel treatment for insomnia disorders.

Daridorexant: A Promising Dual Orexin Receptor Antagonist

The authors describe the research process that led to the identification of daridorexant, a dual orexin receptor antagonist that is currently in Phase 3 clinical trials for the treatment of insomnia.

A New Path to Better Sleep

This study offers hope for individuals struggling with insomnia. Just as a camel finds respite in the shade of an oasis, researchers are searching for ways to help people find relief from sleep disturbances.

Dr.Camel's Conclusion

This study highlights the promise of daridorexant as a potential new treatment for insomnia. Further research is needed, but this research offers a glimmer of hope in the quest for better sleep for individuals with insomnia.
Date :
  1. Date Completed 2021-09-14
  2. Date Revised 2021-09-14
Further Info :

Pubmed ID

32937014

DOI: Digital Object Identifier

10.1002/cmdc.202000453

Related Literature

Article Analysis
・Effects of daridorexant
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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