Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors.

Author: FujiokaYayoi, FujitaHidenori, FunabashiKaoru, HiraiHiroshi, ItoKenjiro, ItoKimihiro, ItoSatoru, MatsuoKenichi, MiuraAkihiro, OchiiwaHiroaki, OhsawaHirokazu, OtsukiSachie, SagaraTakeshi, SootomeHiroshi, YashiroMasakazu, YonekuraKazuhiko

Paper Details 
Original Abstract of the Article :
FGFR signaling is deregulated in many human cancers, and FGFR is considered a valid target in FGFR-deregulated tumors. Here, we examine the preclinical profile of futibatinib (TAS-120; 1-[(3S)-[4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3, 4-d] pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-on...See full text at original site
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引用元:
https://doi.org/10.1158/0008-5472.CAN-19-2568

データ提供:米国国立医学図書館(NLM)

Futibatinib: A Novel Inhibitor Targeting FGFR Signaling in Cancer

Cancer research is a complex and ever-evolving field, like a vast and ever-shifting desert landscape. This research delves into the potential of futibatinib, a novel irreversible inhibitor of fibroblast growth factor receptors (FGFRs), as a targeted therapy for FGFR-deregulated tumors. The study explored the preclinical profile of futibatinib, analyzing its selective inhibition of FGFRs and its antitumor activity in various cancer cell lines and models. It's like searching for a hidden oasis of therapeutic potential in the desert of cancer research.

Futibatinib: A Promising New Weapon in the Fight Against Cancer

This study provides compelling evidence for the potential of futibatinib as a targeted therapy for FGFR-driven cancers. The researchers found that futibatinib exhibited significant and selective antitumor activity in various preclinical models. It's like discovering a new and powerful weapon in the battle against a formidable foe.

The Desert of Cancer Research: A Constant Search for New Solutions

The desert of cancer research is a constant search for new and effective therapies. This study highlights the importance of exploring novel targets and developing innovative drugs that can precisely target specific pathways involved in cancer growth. It's a reminder to persevere in the quest for solutions, always seeking new oases of hope in the vast and challenging landscape of cancer research.

Dr.Camel's Conclusion

This research offers a glimmer of hope for patients with FGFR-driven cancers, providing a promising new therapeutic avenue for this challenging disease. It reinforces the need for continued research and development of targeted therapies, navigating the complex desert of cancer research with determination and innovation.

Date :
  1. Date Completed 2021-02-12
  2. Date Revised 2021-03-16
Further Info :

Pubmed ID

32973082

DOI: Digital Object Identifier

10.1158/0008-5472.CAN-19-2568

Related Literature

SNS
PICO Info
in preparation
Languages

English

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