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A simple automated approach to measure mouse whole gut transit.

Author: AltoAlecia, BeyderArthur, FarrugiaGianrico, GibbonsSimon J, KacmazHalil, KnutsonKaitlyn, LindenDavid R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Measuring the time it takes for a marker to travel through the entire digestive tract in mice is a crucial tool for studying the effects of new drugs on gut motility. This method can help scientists understand how drugs may affect digestion and identify potential side effects.
Paper Details　
Original Abstract of the Article :
Gastrointestinal (GI) motility is a complex physiological process that is critical for normal GI function. Disruption of GI motility frequently occurs in GI diseases or as side effects of therapeutics. Whole gut transit measurements, like carmine red leading-edge transit, in mice form the cornerston...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/33000540

データ提供：米国国立医学図書館（NLM）

Measuring Mouse Gut Transit: A Journey Through the Digestive System

This research focuses on a key aspect of gastrointestinal health: gut motility. Imagine the digestive system as a complex desert ecosystem. Food is like a precious water source that needs to flow smoothly through the system. This study explores a simple, automated approach to measure the movement of food (carmine red) through the digestive system of mice. This is like studying the flow of water through a network of desert oases, helping us understand how the digestive system functions.

Automated Measurement for Studying Gut Motility

The study introduces a new automated method to measure mouse whole gut transit, a crucial aspect of understanding gastrointestinal motility. This method provides valuable insights into the intricate movements of the digestive system, offering a more efficient and accurate way to assess gut health in mice.

Understanding Gut Motility is Essential for Health

Understanding the intricate movements of our digestive system is essential for maintaining overall health. Disruptions in gut motility can lead to a variety of gastrointestinal disorders, and this study helps us understand the factors that contribute to these disruptions.

Dr.Camel's Conclusion

This study provides valuable insights into the complex workings of the gastrointestinal system. By utilizing an automated approach to measure gut transit, researchers can gain a better understanding of how the digestive system functions. It's like discovering a new tool for navigating the vast desert ecosystem of the digestive system, helping us understand the delicate balance that keeps things flowing smoothly.

Date :
  1. Date Completed 2021-11-01
  2. Date Revised 2021-11-01
Further Info :

Pubmed ID

33000540

DOI: Digital Object Identifier

NIHMS1664686

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Languages

English

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