SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer.

Author: ChenHao, LibringSarah, MiaoJinmin, RuddrarajuKasi Viswanatharaju, SolorioLuis, WendtMichael K, ZhangZhong-Yin

Paper Details 
Original Abstract of the Article :
Metastatic breast cancer (MBC) is an extremely recalcitrant disease capable of bypassing current targeted therapies via engagement of several growth promoting pathways. SH2 containing protein tyrosine phosphatase-2 (SHP2) is an oncogenic phosphatase known to facilitate growth and survival signaling ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/33033382

データ提供:米国国立医学図書館(NLM)

Targeting SHP2: A New Oasis in the Desert of Drug-Resistant Breast Cancer

In the challenging landscape of [breast cancer] treatment, overcoming [drug resistance] is a formidable obstacle, like navigating a desert with shifting sands and hidden dangers. This study, like a skilled desert explorer seeking a new path, investigates the therapeutic potential of targeting SHP2, a critical signaling molecule, to combat drug-resistant metastatic breast cancer (MBC). The researchers recognize that MBC, like a resilient desert plant, can adapt and evade traditional therapies.

The researchers, like scientists studying the intricate ecosystem of a desert, investigated the role of SHP2 in MBC cells. They found that SHP2, like a crucial water source in the desert, plays a central role in driving the growth and survival of MBC cells. The study demonstrated that inhibiting SHP2 activity, akin to controlling the flow of water in the desert, effectively blocked the growth of MBC cells, offering a new therapeutic strategy for combatting this challenging disease.

SHP2 Inhibition: A Promising Weapon in the Fight Against Breast Cancer

This study, like a well-equipped caravan setting out on a long journey, provides valuable insights into the potential of SHP2 inhibition as a novel treatment for drug-resistant MBC. The researchers' findings suggest that targeting SHP2, like striking a critical wellspring in the desert, could offer a promising new approach to combatting this aggressive form of cancer, potentially leading to improved outcomes and a brighter future for patients.

Navigating the Desert of Drug Resistance

Navigating the desert of drug resistance in cancer treatment requires a multifaceted approach, like a caravan of experts working together. This study, like a compass guiding us through this challenging terrain, underscores the importance of exploring new therapeutic targets, like SHP2, to overcome the obstacles posed by drug resistance and improve treatment outcomes for patients.

Dr.Camel's Conclusion

This study, like a camel caravan traversing a vast desert landscape, reminds us that the search for new and effective cancer treatments is a continuous journey. The potential of SHP2 inhibition as a therapeutic target offers a beacon of hope in the fight against drug-resistant MBC. This innovative approach, like a refreshing oasis in a parched desert, could lead to improved outcomes and a brighter future for patients facing this challenging disease.

Date :
  1. Date Completed 2021-02-19
  2. Date Revised 2023-07-25
Further Info :

Pubmed ID

33033382

DOI: Digital Object Identifier

NIHMS1632311

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Languages

English

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