Paper Details

  1. Home
  2. Paper Details

Systematic review and meta-analysis of randomized controlled trials on the effects of obeticholic acid on the blood lipid profile: Insights into liver disorders and liver cancer.

Author: GuanLin, MiaoPeng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This meta-analysis found that obeticholic acid (OCA) administration causes significant increases in blood levels of total cholesterol and low-density lipoprotein cholesterol while decreasing high-density lipoprotein cholesterol and triglycerides.
Paper Details　
Original Abstract of the Article :
AIM: Treatment with obeticholic acid (OCA) affects the blood lipid profile. Therefore, a meta-analysis of randomized controlled trials (RCTs) was performed to investigate the effects of OCA on blood lipids and lipoproteins. METHODS AND RESULTS: The electronic databases of PubMed, Web of Science, SC...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.ejphar.2020.173616

データ提供：米国国立医学図書館（NLM）

Obeticholic Acid: Impact on Blood Lipids

In the vast ocean of pharmacological research, [obeticholic acid (OCA)] is a drug that has emerged as a potential therapy for various liver disorders. This study dives into the effects of OCA on blood lipids, investigating its impact on cholesterol and triglyceride levels. The research findings are crucial for understanding the potential benefits and risks associated with OCA treatment.

Obeticholic Acid: Balancing Blood Lipids

The authors discovered that [OCA administration significantly increased blood levels of TC and LDL-C], while simultaneously decreasing HDL-C and TG. Imagine a camel's body as a delicate ecosystem; the levels of cholesterol and triglycerides must be balanced to ensure optimal health. This research provides valuable insights into how OCA influences this delicate balance. The authors suggest that [further research is needed to fully understand the impact of OCA on liver cancer], highlighting the importance of ongoing investigations in this area.

Obeticholic Acid: A Potential Treatment for Liver Disorders

OCA is a promising therapeutic agent for [various liver disorders], but its impact on blood lipids requires careful consideration. Just as a camel adapts its water consumption to the desert environment, so too must we monitor the impact of medications on our bodies. This study serves as a reminder that [while OCA may offer potential benefits, it is crucial to weigh the risks and benefits carefully] when considering treatment options for liver disorders.

Dr.Camel's Conclusion

This meta-analysis sheds light on the impact of obeticholic acid on blood lipids, providing valuable information for clinicians and researchers. Just as a camel adapts to the changing desert landscape, so too must we adapt our understanding of medications and their effects on our bodies. This research serves as a stepping stone in our quest to develop safer and more effective treatments for liver disorders.
Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-05-14
Further Info :

Pubmed ID

33035521

DOI: Digital Object Identifier

10.1016/j.ejphar.2020.173616

Related Literature

Article Analysis
・Effects of obeticholic acid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.