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Effects of CYP2B6 polymorphisms on plasma nevirapine concentrations: a systematic review and meta-analysis.

Author: ChoYoung Ah, GwakHye Sun, YeeJeong, YoonHa Young

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Nevirapine is a drug that is used to treat HIV infection. The metabolism of nevirapine is affected by genetic variations in the cytochrome P450 (CYP) enzymes, particularly CYP2B6. This study investigated the effects of CYP2B6 variants on the plasma concentrations of nevirapine. The study found that patients with the CYP2B6 516TT genotype had higher plasma concentrations of nevirapine than patients with the GG or GT genotypes. This suggests that CYP2B6 genotyping may be useful for predicting the response to nevirapine and for adjusting doses to optimize treatment.
Paper Details　
Original Abstract of the Article :
Cytochrome P450 (CYP) is involved in the metabolism of nevirapine (NVP); especially, CYP2B6 has been known to be one of the main enzymes involved in NVP metabolism. The objective of this study was to investigate the effects of CYP2B6 variants on plasma concentrations of NVP by a systematic review an...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562737/

データ提供：米国国立医学図書館（NLM）

CYP2B6 Polymorphisms: A Key to Personalized Nevirapine Treatment

This study delves into the complex world of drug metabolism, specifically focusing on the impact of CYP2B6 polymorphisms on the efficacy of nevirapine (NVP), a drug used to treat HIV infection. It's like understanding the delicate ecosystem of a desert, where even subtle variations in the soil can influence the growth of a particular plant.

Unveiling the Secrets of Drug Metabolism

The researchers conducted a comprehensive meta-analysis, combining data from multiple studies to investigate the association between CYP2B6 variants and plasma NVP concentrations. Their findings revealed that individuals with specific CYP2B6 genotypes had significantly higher NVP concentrations compared to others. It's like discovering that certain desert plants thrive in specific microclimates due to their unique adaptations.

Towards Personalized Medicine

This research highlights the importance of considering individual genetic variations in drug metabolism when prescribing medications. It's like tailoring a journey through the desert based on the unique capabilities and needs of each traveler. This approach, known as personalized medicine, could lead to more effective and safer drug treatment for patients.

Dr. Camel's Conclusion

This study underscores the importance of understanding individual genetic differences to optimize drug treatment. By considering the unique characteristics of each patient, we can navigate the complexities of drug metabolism and deliver more effective and personalized care.

Date :
  1. Date Completed 2021-03-10
  2. Date Revised 2021-03-10
Further Info :

Pubmed ID

33060725

DOI: Digital Object Identifier

PMC7562737

Related Literature

Article Analysis
・Effects of nevirapine
SNS
PICO Info
in preparation
Languages

English

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