Application of ZnO/CNT@Fe<sub>3</sub>O<sub>4</sub>nanocomposite in amplifying the anti-leukemic effects of Imatinib: a novel strategy to adjuvant therapy in chronic myeloid leukemia.

Author: BashashDavood, FakhroueianZahra, MomenyMajid, Pourbagheri-SigaroodiAtieh, Safaroghli-AzarAva, YousefiAmir-Mohammad

Paper Details 
Original Abstract of the Article :
The advent of tyrosine kinase inhibitors in the therapeutic protocols of chronic myeloid leukemia (CML) was a revolution in the treatment strategies that guaranteed the achievement of complete remission for patients. However, due to different mutations bypassing the efficacy of Imatinib, novel and m...See full text at original site
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引用元:
https://doi.org/10.1088/1748-605X/abcae2

データ提供:米国国立医学図書館(NLM)

Amplifying the Anti-Leukemic Effects of Imatinib with a Novel Nanocomposite

The field of [chronic myeloid leukemia (CML) treatment] is always searching for more effective ways to combat this debilitating disease. This study delves into the potential of a [ZnO/CNT@Fe3O4 nanocomposite] as a novel adjuvant therapy to enhance the efficacy of [Imatinib], a tyrosine kinase inhibitor that has revolutionized CML treatment. The authors investigated the effects of combining this nanocomposite with Imatinib on the survival of CML-derived K562 cells. Their research reveals that this combination significantly decreased the survival of these cells, likely due to the induction of apoptosis mediated by reactive oxygen species. Furthermore, the study discovered that this treatment's apoptotic effect was amplified by autophagy suppression, suggesting a promising therapeutic strategy for [CML treatment].

A New Strategy for Adjuvant Therapy in CML

The findings of this study point towards a novel approach for treating CML. The nanocomposite's ability to enhance the anti-cancer effects of Imatinib in K562 cells suggests that it could be a valuable tool for combined-strategy treatment. This research highlights the potential of nanomaterials in treating CML, potentially leading to improved treatment outcomes for patients.

Harnessing the Power of Nanocomposite for Effective CML Treatment

This research offers hope for patients with CML. By understanding the mechanisms of action of this nanocomposite and its synergistic effects with Imatinib, scientists can develop more targeted and effective treatments. The future of CML treatment may lie in the integration of nanotechnology, offering patients a better chance at remission and a healthier life.

Dr.Camel's Conclusion

This research is like a camel caravan traversing the vast desert of CML treatment, carrying new hope for a more effective cure. The discovery of this nanocomposite is like finding a hidden oasis, offering a powerful tool to combat this disease. As a dedicated researcher, I am excited about the potential of this novel approach and eagerly await further research to explore its full potential in clinical settings.

Date :
  1. Date Completed 2022-03-31
  2. Date Revised 2022-04-01
Further Info :

Pubmed ID

33197900

DOI: Digital Object Identifier

10.1088/1748-605X/abcae2

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