Paper Details

  1. Home
  2. Paper Details

Long-Term Safety and Clinical Effects of Nilotinib in Parkinson's Disease.

Author: AhnJaeil, FerranteDalila, HebronMichaeline L, MatarSara, MoussaCharbel, MulkiSanjana, PaganFernando L, Torres-YaghiYasar, WilmarthBarbara

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the safety, tolerability, and potential clinical effects of nilotinib in Parkinson's disease. The study found that nilotinib was safe and tolerated. Exploratory clinical outcomes showed that nilotinib 300mg was remarkably stable from baseline to 27 months using the Unified Parkinson's Disease Scale (UPDRS). A larger study is needed to evaluate the efficacy of nilotinib 300mg in Parkinson's disease.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Nilotinib is US Food and Drug Administration-approved for leukemia, and this open-label study investigated the safety, tolerability, and potential clinical effects of nilotinib in medically optimized patients with Parkinson's disease. OBJECTIVES: Safety and tolerability were the primary...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048914/

データ提供：米国国立医学図書館（NLM）

Nilotinib's Safety and Potential Clinical Effects in Parkinson's Disease

Parkinson's disease is a neurodegenerative disorder that affects millions worldwide. This research investigates the safety and potential clinical effects of a drug called nilotinib, typically used to treat leukemia, in patients with Parkinson's disease.

Nilotinib Shows Promise as a Potential Parkinson's Disease Treatment

The study involved 63 patients with Parkinson's disease who received nilotinib at either 150 mg or 300 mg daily. The results showed that nilotinib was safe and well-tolerated. Interestingly, the study observed a potential benefit of nilotinib in maintaining or even improving Parkinson's disease symptoms, particularly at the higher dose. These findings warrant further investigation into the potential therapeutic role of nilotinib in managing Parkinson's disease.

New Horizons in Parkinson's Disease Treatment

This research provides exciting new insights into the potential of nilotinib for treating Parkinson's disease. The findings suggest that this drug, already used for leukemia, might also offer benefits for individuals with Parkinson's. Further research is needed to confirm these observations and investigate the long-term effects of nilotinib in this context. However, this study offers a glimmer of hope for finding new and effective treatments for this debilitating disease.

Dr. Camel's Conclusion

Just as a desert traveler may discover a hidden oasis offering relief from the harsh environment, researchers are exploring new avenues for treating Parkinson's disease. The potential of nilotinib represents a promising step forward in this journey, offering a ray of hope for improved outcomes for patients with this challenging condition.

Date :
  1. Date Completed 2021-04-23
  2. Date Revised 2022-01-14
Further Info :

Pubmed ID

33215762

DOI: Digital Object Identifier

PMC8048914

Related Literature

Article Analysis
・Effects of nilotinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.