Paper Details

  1. Home
  2. Paper Details

Natural prevalence of NS3 gene resistance-associated substitutions (RASs) in patients with chronic hepatitis C from the state of Pará/Brazil.

Author: FreitasPedro Eduardo Bonfim, NunesHeloisa Marceliano, da SilvaDesirée Lopes

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study identified and established the natural prevalence of RASs in the NS3 gene in patients with chronic hepatitis C in the state of Pará, northern Brazil. The general natural prevalence of RASs in the NS3 gene was 37.5 % (Y56F and S122T).
Paper Details　
Original Abstract of the Article :
The resistance of hepatitis C virus (HCV) to direct-acting antiviral agents, used in chronic hepatitis C treatment, consists of a natural process resulting from resistance-associated substitutions (RASs) at specific amino acid regions. To identify and establish the natural prevalence of RASs in the ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.virusres.2020.198251

データ提供：米国国立医学図書館（NLM）

Hepatitis C: Understanding Resistance to Antiviral Treatment

Hepatitis C, a viral infection that can cause liver damage, requires effective treatment. This research investigates the prevalence of resistance-associated substitutions (RASs) in the NS3 gene of hepatitis C virus (HCV). The authors analyzed samples from patients infected with HCV genotype 1, identifying the presence of RASs in a significant proportion of patients. This research provides valuable insights into the genetic variability of HCV and the challenges associated with antiviral treatment.

Resistance to Antiviral Treatment: A Complex Issue in Hepatitis C

The research highlights the importance of understanding the genetic variability of HCV and the challenges associated with antiviral treatment. It emphasizes the need for ongoing monitoring and research to develop more effective treatment strategies.

The Importance of Understanding Viral Resistance

This research underscores the importance of understanding viral resistance in developing effective treatment strategies for infectious diseases. It highlights the need for ongoing research to identify and overcome viral resistance.

Dr. Camel's Conclusion

This research provides important insights into the prevalence of resistance-associated substitutions in HCV, highlighting the challenges associated with antiviral treatment. It emphasizes the need for ongoing research to develop more effective treatment strategies for hepatitis C.
Date :
  1. Date Completed 2021-10-05
  2. Date Revised 2021-10-05
Further Info :

Pubmed ID

33259871

DOI: Digital Object Identifier

10.1016/j.virusres.2020.198251

Related Literature

Article Analysis
・Effects of simeprevir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.