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S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug Resistance in p53 Deleted Colon Cancer Cells.

Author: BorzacchielloLuigi, CacciapuotiGiovanna, MeleLuigi, MoscaLaura, PaganoMartina, PecoraroAnnalisa, PorcelliMarina, RussoAnnapina, RussoGiulia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

S-adenosyl-l-methionine (SAMe) is a natural compound that has shown anticancer and anti-proliferative effects. This abstract investigates the potential of SAMe in overcoming drug resistance in colon cancer cells that lack the p53 gene, a key tumor suppressor.
Paper Details　
Original Abstract of the Article :
In order to study novel therapeutic approaches taking advantage of natural compounds showing anticancer and anti-proliferative effects, we focused our interest on S-adenosyl-l-methionine, a naturally occurring sulfur-containing nucleoside synthesized from adenosine triphosphate and methionine by met...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795960/

データ提供：米国国立医学図書館（NLM）

S-Adenosyl-l-Methionine: A Potential Weapon Against Drug Resistance in Colon Cancer

Cancer is a formidable foe, often likened to a relentless desert sandstorm, relentlessly attacking the body. This study explores the potential of S-adenosyl-l-methionine (SAMe), a naturally occurring compound, in overcoming drug resistance in colon cancer cells that lack the p53 gene, a tumor suppressor gene.

The researchers investigated the effects of SAMe on drug resistance in p53-deleted colon cancer cells. Their findings suggest that SAMe can overcome drug resistance by inhibiting the activity of the uL3 protein, which plays a role in drug resistance. This discovery holds promise for developing new therapeutic approaches to combat drug resistance in colon cancer.

Fighting the Sandstorm of Cancer

This study offers a new avenue for combating drug resistance in colon cancer. The findings suggest that SAMe, a naturally occurring compound, may hold the key to overcoming this critical challenge, potentially leading to more effective treatments for this type of cancer.

Finding New Paths to Victory

This study is a reminder that even in the face of a formidable foe like cancer, research and innovation can lead to breakthroughs. It’s a testament to the power of science to find new paths to victory and improve the lives of those affected by this devastating disease.

Dr.Camel's Conclusion

This research provides a promising avenue for overcoming drug resistance in colon cancer. The findings suggest that SAMe, a naturally occurring compound, has the potential to enhance the effectiveness of cancer treatments. This discovery underscores the importance of continued research in developing new and effective therapies to combat cancer.

Date :
  1. Date Completed 2021-09-06
  2. Date Revised 2022-10-13
Further Info :

Pubmed ID

33374288

DOI: Digital Object Identifier

PMC7795960

SNS
PICO Info
in preparation
Languages

English

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