Efficacy of a Topical Product Containing Purified Omental Lipids and Three Anti-Itching Compounds in the Treatment of Chronic Pruritus/Prurigo Nodularis in Elderly Subjects: A Prospective, Assessor-Blinded, 4-Week Trial with Transepidermal Water Loss and Optical Coherence Tomography Assessments.

Author: ArdigòMarco, BianchiLuca, CampioneElena, CosioTerenzio, FranceschiniChiara, LannaCaterina, MilaniMassimo

Paper Details 
Original Abstract of the Article :
PURPOSE: To investigate the efficacy of a cream containing purified omental lipids 10% and three anti-itching substances (polidocanol/stimutex/palmitoylethanolamine) in elderly subjects with chronic pruritus/prurigo nodularis (CP/CPN). PATIENTS AND METHODS: Thirty-five subjects (6 men; mean age 67±...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7779310/

データ提供:米国国立医学図書館(NLM)

A Topical Cream for Chronic Pruritus/Prurigo Nodularis in Elderly Subjects

Chronic pruritus, a persistent and often debilitating itch, can significantly impact quality of life, particularly in elderly individuals. This study investigates the efficacy of a topical cream containing purified omental lipids and three anti-itching compounds in treating chronic pruritus/prurigo nodularis (CP/CPN) in elderly subjects. The researchers conduct a prospective, assessor-blinded, 4-week trial to assess the cream's effectiveness in reducing itch intensity, improving skin barrier function, and modifying skin structure.

A Promising Topical Treatment for Chronic Itch

This study demonstrates the efficacy of a topical cream containing purified omental lipids and three anti-itching compounds in significantly reducing itch intensity in elderly subjects with CP/CPN. The researchers observed a substantial reduction in itch severity scores using both visual analogue itch severity scale (VAS) and verbal itching rating scale (VRS). The cream's effectiveness is further supported by the observed improvements in skin barrier function, as evidenced by a reduction in transepidermal water loss (TEWL), and structural changes in the skin, as observed through optical coherence tomography (OCT) assessments.

Easing the Burden of Chronic Itch

This study highlights the potential of a topical cream containing purified omental lipids and three anti-itching compounds as a promising treatment option for CP/CPN in elderly subjects. The cream's effectiveness in reducing itch intensity, improving skin barrier function, and modifying skin structure suggests a multi-pronged approach to managing this debilitating condition. The findings suggest a potential for improving the quality of life for individuals experiencing chronic itch, allowing them to enjoy greater comfort and well-being. You know, just like a camel can withstand the harsh sun and dryness of the desert, this topical cream can provide much-needed relief from the relentless itch of CP/CPN.

Dr. Camel's Conclusion

This prospective trial demonstrates the efficacy of a topical cream containing purified omental lipids and three anti-itching compounds in significantly reducing itch intensity and improving skin health in elderly subjects with chronic pruritus/prurigo nodularis (CP/CPN). The cream's effectiveness in reducing itch intensity, improving skin barrier function, and modifying skin structure suggests a potential for improving the quality of life for individuals experiencing chronic itch. This research offers a promising avenue for managing CP/CPN, a condition that can severely impact the well-being of elderly individuals. You know, just like a camel can navigate the harsh desert environment, this topical cream can offer a soothing respite from the discomfort of chronic itch.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-19
Further Info :

Pubmed ID

33408496

DOI: Digital Object Identifier

PMC7779310

Related Literature

SNS
PICO Info
in preparation
Languages

English

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