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Phase II clinical trial of nab-paclitaxel plus gemcitabine in elderly patients with previously untreated locally advanced or metastatic pancreatic adenocarcinoma: the BIBABRAX study.

Author: AlberoAna, Casado GonzalezEsther, Delgado-MingoranceJuan Ignacio, FeliuJaime, Fernández MontesAna, García PiernaviejaCarmen, González CebriánIrene, González GonzálezJosé Federico, Jorge FernándezMónica, López MuñozAna María, López-VivancoGuillermo, MacarullaTeresa, MassutiBartomeu, Mondéjar SolísRebeca, Quintero-AldanaGuillermo, Valladares-AyerbesManuel, VicentePilar

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The combination of nab-paclitaxel and gemcitabine in an elderly population with pancreatic cancer improved survival and clinical response, but did not confirm a benefit in terms of quality-of-life.
Paper Details　
Original Abstract of the Article :
PURPOSE: To evaluate the health-related quality of life (HRQoL), global health status (GHS), and deterioration-free survival of an elderly population (> 70 years) with unresectable locally advanced (LAPC) or metastatic pancreatic cancer (mPC) treated with nab-paclitaxel in combination with gemcitabi...See full text at original site
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引用元：
https://doi.org/10.1007/s00280-020-04214-w

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Pancreatic Cancer: Exploring a Treatment Option for Elderly Patients

Pancreatic cancer, a challenging diagnosis, often feels like navigating a vast and unforgiving desert. This study investigates the effectiveness of a combination therapy involving nab-paclitaxel and gemcitabine in elderly patients with previously untreated locally advanced or metastatic pancreatic cancer. The researchers conducted a phase II clinical trial, enrolling 80 patients over the age of 70. The results demonstrate that this combination therapy significantly improved overall survival and clinical response, showing promise as a treatment option for elderly patients with pancreatic cancer.

The Oasis of Combined Therapy: Improving Survival and Response

This study demonstrates the effectiveness of a combination therapy of nab-paclitaxel and gemcitabine in elderly patients with pancreatic cancer. The results indicate that this treatment significantly improved overall survival and clinical response, offering a beacon of hope for this patient population.

Navigating the Desert of Cancer: Seeking Support and Personalized Care

Pancreatic cancer is a challenging disease, and the journey to recovery can be arduous. This study highlights the importance of exploring potential treatment options and working closely with a healthcare professional to develop a personalized care plan.

Dr.Camel's Conclusion

This research provides a glimmer of hope in the desert of pancreatic cancer, offering a potential treatment option for elderly patients. The findings emphasize the importance of exploring combination therapies and personalized care approaches for this complex and challenging disease.

Date :
  1. Date Completed 2021-08-24
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

33452559

DOI: Digital Object Identifier

10.1007/s00280-020-04214-w

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Article Analysis
・Effects of paclitaxel (with albumin) injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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