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The Effect of Iron Supplementation on FGF23 in Chronic Kidney Disease Patients: a Systematic Review and Time-Response Meta-Analysis.

Author: Abu-ZaidAhmed, AldehamiMohammad Abdulrahman, BehiryAbdulrahman Adel, BhagavathulaAkshaya Srikanth, HajjiRaouf, MagzoubDuha

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Iron treatment was associated with a significant decrease in FGF23 levels in CKD patients. Oral iron therapy was more effective than intravenous iron therapy.
Paper Details　
Original Abstract of the Article :
Fibroblast growth factor 23 (FGF23) gene is found to be responsible for autosomal dominant hypophosphatemic rickets, and is highly expressed in chronic kidney disease (CKD) and end-stage renal disease patients with iron deficiency anemia (IDA). We evaluated the efficacy of different iron treatments ...See full text at original site
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引用元：
https://doi.org/10.1007/s12011-021-02598-1

データ提供：米国国立医学図書館（NLM）

Iron Supplementation and FGF23: A Quest to Restore Balance in CKD

Chronic kidney disease (CKD), a condition affecting millions, is like a slow desert erosion, gradually eroding the body's ability to function properly. Iron deficiency anemia (IDA), a common complication of CKD, further weakens the body, like a parched oasis struggling to thrive. This study, like a search for hidden springs of renewal, explores the effects of iron supplementation on FGF23 levels in CKD patients with IDA.

The researchers, like desert explorers seeking to restore balance, analyzed data from randomized controlled trials. Their findings, like a revitalized oasis, suggest that iron treatment, particularly oral iron therapy, can significantly reduce FGF23 levels in CKD patients with IDA. This suggests that iron supplementation may play a crucial role in restoring balance to the body's delicate systems.

Iron's Role in CKD: A Vital Nutrient for Renewal

This study, like a compass guiding us through the desert of CKD, reveals the importance of iron in managing this challenging condition. The findings demonstrate that iron supplementation, particularly oral iron therapy, can effectively reduce FGF23 levels, suggesting a potential for improving overall health and well-being in CKD patients.

A Path to Improved Health: Restoring Balance with Iron

The desert of CKD can be a challenging place, but this study offers hope by highlighting the role of iron in restoring balance. Iron supplementation, particularly oral iron therapy, may offer a valuable tool for managing CKD and improving the health of patients with IDA.

Dr.Camel's Conclusion

CKD can be a difficult journey, but this study provides valuable insights into the potential of iron to restore balance and improve health outcomes. The findings suggest that iron supplementation may hold the key to revitalizing the body and creating a more sustainable path for CKD patients.

Date :
  1. Date Completed 2021-10-18
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

33462793

DOI: Digital Object Identifier

10.1007/s12011-021-02598-1

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Languages

English

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