Paper Details

  1. Home
  2. Paper Details

Network meta-analysis of biologic treatments for psoriasis using absolute Psoriasis Area and Severity Index values ≤1, 2, 3 or 5 derived from a statistical conversion method.

Author: DossenbachM, HartzS, LeonardiC L, MrowietzU, PettoH, ReichK, SaureD, WarrenR B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

The goal of psoriasis treatment is to have clear or almost clear skin and keep the condition under control. However, it's hard to define exact scores on a scale called PASI (Psoriasis Area and Severity Index) that represent these goals, as most studies report improvements compared to the starting score, rather than the final scores achieved.
Paper Details　
Original Abstract of the Article :
In practice, the goal of treatment for patients with psoriasis is to achieve almost clear or clear skin and maintain disease control, regardless of baseline disease severity. However, identifying absolute Psoriasis Area and Severity Index (PASI) values for new treatment goals is challenging, as most...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248394/

データ提供：米国国立医学図書館（NLM）

A New Approach to Psoriasis Treatment: Achieving Clear Skin

Greetings from Dr. Camel, your guide through the intricate world of [psoriasis]. Psoriasis, a chronic skin condition, is like a stubborn desert sandstorm that refuses to settle. This research dives into the realm of biological treatments for psoriasis, focusing on achieving clear or almost clear skin. The challenge lies in identifying the absolute Psoriasis Area and Severity Index (PASI) values that correspond to these desired treatment goals. While most clinical trials report relative PASI improvements, absolute PASI values are rarely reported. This study presents a statistical conversion method to derive absolute PASI values from relative PASI improvements, providing a more comprehensive picture of treatment outcomes.

A Roadmap to Clear Skin

This research provides a valuable tool for evaluating the effectiveness of psoriasis treatments by establishing a method to convert relative PASI improvements into absolute PASI values. This approach allows us to better understand the actual level of skin clearance achieved by different treatments, much like navigating a desert with a reliable map. This method can help in making more informed treatment decisions, ultimately leading to better outcomes for psoriasis patients.

Towards a Clear Future

This study offers hope for those struggling with psoriasis. By providing a more accurate way to assess treatment outcomes, it contributes to a more personalized and effective approach to managing this challenging condition. It's a step closer to achieving clear skin and a better quality of life for those living with psoriasis, much like finding a clear path through a vast and challenging desert.

Dr. Camel's Conclusion

This study presents a valuable innovation in the field of psoriasis research. The statistical conversion method for deriving absolute PASI values offers a more comprehensive way to evaluate treatment effectiveness, empowering healthcare providers to make more informed treatment decisions. It's a reminder that in the vast desert of medical research, innovative approaches can lead to improved outcomes for patients.

Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-07-07
Further Info :

Pubmed ID

33480102

DOI: Digital Object Identifier

PMC8248394

Related Literature

Article Analysis
・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.