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Adverse Events of Thiopurine Therapy in Pediatric Inflammatory Bowel Disease and Correlations with Metabolites: A Cohort Study.
Author: BenningaMarc A, BuiterHans J C, JagtJasmijn Z, PothofChristine D, de BoerNanne K H, de MeijTim G J, van LimbergenJohan E, van WijkMichiel P
Original Abstract of the Article :
BACKGROUND: In the recent era of growing availability of biological agents, the role of thiopurines needs to be reassessed with the focus on toxicity. AIMS: We assessed the incidence and predictive factors of thiopurine-induced adverse events (AE) resulting in therapy cessation in pediatric inflamm...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8741678/
データ提供：米国国立医学図書館（NLM）
Understanding Thiopurine Therapy in Pediatric IBD
Inflammatory bowel disease (IBD), a chronic inflammatory condition affecting the digestive tract, poses significant challenges for children and their families. This research investigates the safety and effectiveness of thiopurine therapy, a common treatment for pediatric IBD, exploring the incidence and factors associated with adverse events (AE) leading to treatment discontinuation. The authors analyze data from a cohort of children with IBD treated with thiopurines, investigating the relationship between thiopurine metabolites and biochemical abnormalities.
Navigating the Challenges of Thiopurine Therapy
This research provides valuable insights into the challenges and complexities of thiopurine therapy in pediatric IBD. The study's findings highlight the need for careful monitoring and individualized treatment plans to minimize the risk of AE while maximizing the benefits of thiopurine therapy. The authors emphasize the importance of understanding the role of thiopurine metabolites and their potential impact on biochemical abnormalities.
A Delicate Balance in Pediatric IBD Treatment
The study underscores the delicate balance in managing pediatric IBD, emphasizing the need for careful consideration of treatment risks and benefits. Imagine a camel navigating a treacherous desert path, carefully choosing its steps to avoid hazards and reach its destination. Similarly, managing pediatric IBD requires a thoughtful approach that balances the potential benefits of treatment with the risks associated with medications.
Dr. Camel's Conclusion
This research provides a valuable resource for clinicians and families navigating the complexities of pediatric IBD and thiopurine therapy. The study highlights the importance of careful monitoring, individualized treatment plans, and understanding the relationship between thiopurine metabolites and biochemical abnormalities. Like a camel traversing a challenging desert landscape, managing pediatric IBD requires a collaborative effort, careful navigation, and unwavering dedication to ensuring the best possible outcomes for children with this chronic condition.
Date :
- Date Completed 2022-02-16
- Date Revised 2022-05-31
Further Info :
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