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Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts.

Author: HerlofsonBente B, KrügerTormod B, LianAina M, ReselandJanne E, SyversenUnni

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the effects of alendronate (ALN), a bisphosphonate, and omeprazole (OME), a proton pump inhibitor, alone and in combination on primary human osteoblasts and gingival fibroblasts in vitro.
Paper Details　
Original Abstract of the Article :
Due to gastrointestinal side effects of oral bisphosphonates (BPs), proton pump inhibitors (PPIs) are often prescribed. PPIs may enhance the risk of osteonecrosis of the jaw, a rare side effect of BPs. Therefore, the objective of this study was to evaluate the effects of the oral BP alendronate (ALN...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856318/

データ提供：米国国立医学図書館（NLM）

Alendronate and Omeprazole: A Combined Approach for Bone Health?

Osteoporosis, a condition characterized by weak and brittle bones, can feel like a fragile desert landscape, vulnerable to erosion. This study investigates the combined effects of alendronate (ALN), a bisphosphonate medication used to treat osteoporosis, and omeprazole (OME), a proton pump inhibitor often prescribed to manage gastrointestinal side effects of bisphosphonates.

A Combined Strategy: A New Oasis for Bone Health?

The authors explored the effects of ALN and OME, both alone and in combination, on human osteoblasts and gingival fibroblasts in vitro. Their findings suggest that the combination of ALN and OME could potentially reduce angiogenic and growth signals from osteoblasts, like a carefully orchestrated irrigation system in a desert oasis.

Navigating the Complexities of Bone Health

The study highlights the need for further research to fully understand the long-term effects of combining ALN and OME, emphasizing the importance of balancing potential benefits with potential risks, like finding a sustainable path through the desert landscape of bone health.

Dr.Camel's Conclusion

This study investigates the combined effects of alendronate and omeprazole on human osteoblasts and gingival fibroblasts. The authors suggest that this combination could potentially reduce angiogenic and growth signals, offering a new avenue for exploring the management of osteoporosis. However, they emphasize the need for further research to fully understand the long-term effects of this combination.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-20
Further Info :

Pubmed ID

33553512

DOI: Digital Object Identifier

PMC7856318

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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