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Therapeutic update of biologics and small molecules for scalp psoriasis: a systematic review.

Author: CamelaElisa, CinelliEleonora, FabbrociniGabriella, MegnaMatteo, Ocampo-GarzaSonia Sofía, VillaniAlessia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Scalp psoriasis is one of the hardest types of psoriasis to treat, causing discomfort and affecting quality of life. It's often difficult to treat because the scalp is sensitive to medication and doesn't always respond well to standard treatments. While newer medications like biologics and small molecules have improved psoriasis treatment, including scalp psoriasis, there's a lack of clear guidelines for managing scalp psoriasis specifically. This review examines the effectiveness and safety of these newer medications for scalp psoriasis, finding that the newest biologics, which target specific proteins in the immune system (IL-17 and IL-23), seem to work best. However, there isn't enough research comparing different treatments directly. Ultimately, the best treatment for scalp psoriasis needs to be individualized.
Paper Details　
Original Abstract of the Article :
Scalp psoriasis represents the most common difficult-to-treat area in psoriasis patients. Its presence is linked to severe discomfort and impairment of quality of life given the associated symptoms (most of all, scaling and pruritus) and the location in a highly visible area, thus a prompt treatment...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/dth.14857

データ提供：米国国立医学図書館（NLM）

Scalp Psoriasis: A Desert of Challenges for Treatment

Psoriasis, a chronic skin condition, can be a real desert of challenges for patients, especially when it affects the scalp. This research dives into the therapeutic landscape of scalp psoriasis, exploring the effectiveness and safety of various treatments, including biologics and small molecules. They used a systematic review methodology to analyze existing evidence, uncovering the exciting potential of newer biologics like anti-IL-17 and anti-IL-23 in effectively controlling scalp psoriasis.

A Guiding Oasis in the Treatment Desert

The study discovered that these newer biologics often lead to better clinical outcomes than traditional treatments. However, they also highlighted a need for more head-to-head comparisons between these newer drugs, emphasizing that treatment selection should be individualized to each patient. This finding reminds us that there is no one-size-fits-all solution in the vast desert of psoriasis.

Navigating the Treatment Desert: Personalized Approaches

This study underscores the need for personalized treatment plans, tailored to each patient's unique situation. It's like finding the perfect oasis in the desert – it requires careful consideration of the individual's needs and the diverse landscape of available treatments.

Dr. Camel's Conclusion

This comprehensive research has unearthed valuable insights into the treatment landscape of scalp psoriasis, highlighting the potential of newer biologics and the importance of personalized medicine in this challenging condition. The study acts as a beacon guiding patients and clinicians towards a more effective and personalized path to managing scalp psoriasis.

Date :
  1. Date Completed 2021-05-25
  2. Date Revised 2021-05-25
Further Info :

Pubmed ID

33559275

DOI: Digital Object Identifier

10.1111/dth.14857

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Article Analysis
・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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