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The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model.

Author: HerloRasmus, HouHuishu, KellyMichael E, MeherVedashree, PeelingLissa, PushieM Jake, SalmanMootaz M, SylvainNicole J

Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Trifluoperazine (TFP), an FDA-approved drug, effectively reduced cerebral edema in post-stroke mice by inhibiting AQP4 expression. This suggests TFP could be a potential treatment for stroke-induced brain edema.
Paper Details　
Original Abstract of the Article :
Stroke is the second leading cause of death and the third leading cause of disability globally. Edema is a hallmark of stroke resulting from dysregulation of water homeostasis in the central nervous system (CNS) and plays the major role in stroke-associated morbidity and mortality. The overlap betwe...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbamem.2021.183573

データ提供：米国国立医学図書館（NLM）

Trifluoperazine for Brain Edema After Stroke

This study investigates the potential of trifluoperazine (TFP), an FDA-approved drug, for treating brain edema in the early acute phase of stroke. The study utilizes a photothrombotic stroke model in mice to evaluate TFP's effects on brain edema, aquaporin-4 (AQP4) expression, and metabolic markers.

A Potential New Treatment for Stroke

The study demonstrates that TFP effectively reduces cerebral edema during the early acute phase of stroke in mice, suggesting its potential as a novel therapeutic strategy for managing this critical complication. The study also shows that TFP inhibits AQP4 expression, highlighting its potential for targeting a key mechanism involved in brain edema formation.

Seeking Relief in the Wake of Stroke

This research, like a desert oasis offering solace after a long and arduous journey, explores the potential of TFP for mitigating the devastating effects of brain edema after stroke. The findings provide hope for the development of new and effective therapies to combat this critical complication.

Dr.Camel's Conclusion

This study offers a glimmer of hope for stroke patients, exploring the potential of TFP to combat brain edema. Like a desert traveler seeking refuge in a hidden oasis, this research paves the way for new and innovative treatments for stroke.

Date :
  1. Date Completed 2021-09-08
  2. Date Revised 2021-09-08
Further Info :

Pubmed ID

33561476

DOI: Digital Object Identifier

10.1016/j.bbamem.2021.183573

Related Literature

Article Analysis
・Effects of trifluoperazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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