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AVP-786 as a promising treatment option for Alzheimer's Disease including agitation.

Author: ChakkamparambilBinu, GrossbergGeorge T, KhouryRita, MarxCharlotte, MirgatiSidney, VeluryDivya

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review examines AVP-786, a deuterated form of dextromethorphan/quinidine, as a potential treatment for agitation in Alzheimer's disease (AD). AVP-786 has shown promise as a safe and potentially effective treatment for agitation in AD. While phase III trials showed mixed findings, future studies with improved study designs and assessments are needed to further evaluate its efficacy and safety.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: To date, there is no FDA-approved treatment for agitation in Alzheimer's disease (AD). Medications currently used off-label have modest clinical efficacy and serious side effects. AREAS COVERED: The authors review the pharmacology, mechanism of action, pharmacokinetics, efficacy, safe...See full text at original site
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引用元：
https://doi.org/10.1080/14656566.2021.1882995

データ提供：米国国立医学図書館（NLM）

AVP-786: A Potential Oasis in the Desert of Alzheimer's Disease

This study delves into the complex and challenging world of Alzheimer's disease, a condition that can feel like a desert of cognitive decline and behavioral changes. The authors, like scientists searching for a cure, examine the potential of AVP-786, a medication, for treating agitation in Alzheimer's patients. AVP-786 is a deuterated form of dextromethorphan/quinidine, which is already approved for treating Pseudo-Bulbar Affect. The researchers highlight AVP-786's potential as a safe and effective treatment for agitation in Alzheimer's disease. While phase III trials showed mixed findings, further research with innovative study designs is ongoing to determine its effectiveness and optimize its use.

AVP-786: A Potential Solution for Navigating the Desert of Agitation

This study suggests that AVP-786 could be a promising and safe treatment for agitation in Alzheimer's disease. While phase III trials showed mixed findings, the researchers are optimistic about the potential of this medication and are continuing research with innovative study designs to determine its effectiveness and optimize its use.

Hope for Navigating the Desert of Agitation

This research offers hope for individuals and families affected by Alzheimer's disease, particularly those struggling with agitation. While further research is needed, the potential of AVP-786 as a safe and effective treatment is a significant development, providing a potential path towards better management of this challenging condition.

Dr.Camel's Conclusion

Alzheimer's disease is like a vast and unforgiving desert, with cognitive decline and behavioral changes creating a difficult landscape to navigate. This study offers a glimmer of hope, suggesting that AVP-786 could be a potential oasis in this desert. While more research is needed, the potential of this medication to alleviate agitation is a significant development. It provides a beacon of hope for individuals and families struggling with this challenging condition, offering the promise of a more comfortable and manageable journey through this difficult terrain.

Date :
  1. Date Completed 2021-05-18
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

33615952

DOI: Digital Object Identifier

10.1080/14656566.2021.1882995

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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