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Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.

Author: , BernardGordon R, BrownSamuel M, BuchmanTimothy G, BusseLaurence W, CoopersmithCraig M, DeWildeChristine, ElyE Wesley, EyzaguirreLindsay M, FowlerAlpha A, GaieskiDavid F, GongMichelle N, HagerDavid N, HallAlex, HinsonJeremiah S, HooperMichael H, KelenGabor D, KhanAkram, LevineMark A, LewisRoger J, LindsellChris J, MarlinJessica S, MartinGreg S, McGlothlinAnna, MooreBrooks L, NugentKatherine L, NwosuSamuel, PolitoCarmen C, RiceTodd W, RickettsErin P, RothmanRichard E, RudolphCaroline C, SanfilippoFred, SevranskyJonathan E, VieleKert, WrightDavid W

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This multicenter, randomized, double-blind, placebo-controlled trial investigated the effect of a combination of vitamin C, thiamine, and hydrocortisone on ventilator- and vasopressor-free days in patients with sepsis. The study found no significant difference between the intervention and placebo groups for the primary outcome. While the trial was terminated early for administrative reasons, the findings suggest that this treatment combination may not be effective in improving these outcomes.
Paper Details　
Original Abstract of the Article :
IMPORTANCE: Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis. OBJECTIVE: To determine whether a combination of vitamin C, thiamine, and hydrocortisone e...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903252/

データ提供：米国国立医学図書館（NLM）

Vitamin C, Thiamine, and Hydrocortisone for Sepsis: The VICTAS Trial

In the vast and often treacherous desert of [sepsis] research, scientists are constantly searching for effective treatments for this life-threatening condition. This study, known as the [VICTAS] trial, investigated the potential benefits of a combination of [vitamin C], [thiamine], and [hydrocortisone] for managing [sepsis] in critically ill patients.

The VICTAS Trial: A Search for Improved Sepsis Treatment

The study, however, concluded that the combination of [vitamin C], [thiamine], and [hydrocortisone] did not significantly [increase ventilator- and vasopressor-free days] compared to [placebo] in patients with [sepsis]. This finding highlights the need for further research to explore the potential of these treatments and to refine their application for patients with [sepsis].

Sepsis Treatment: A Challenging Landscape

This study reminds us of the challenging nature of [sepsis] research. Despite the promising findings of some studies, it is crucial to conduct rigorous trials to fully understand the effectiveness and safety of potential treatments. As we continue to navigate the desert of [sepsis] research, we need to be vigilant in our pursuit of effective treatments for this devastating condition.

Dr.Camel's Conclusion

The [VICTAS] trial serves as a reminder that the desert of [sepsis] research is full of surprises. While this particular study didn't yield the desired results, we must continue our exploration to find better treatments for patients facing this challenging condition.

Date :
  1. Date Completed 2021-03-02
  2. Date Revised 2022-03-04
Further Info :

Pubmed ID

33620405

DOI: Digital Object Identifier

PMC7903252

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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