One-year efficacy and safety of naloxegol on symptoms and quality of life related to opioid-induced constipation in patients with cancer: KYONAL study.

Author: Beato ZambranoCarmen, Blancas López-BarajasMaría Isabel, Cabezón-GutiérrezLuis, Chicas-SettRodolfo, Cobo DolsManuel, Delgado MingoranceIgnacio, Fírvida PérezJosé Luis, García NavalónFrancisco Javier, Giraldo MarínAlexandra, Higuera GómezOliver, Huerta GonzálezIbone, Librán OriolAnna, Moreno MuñozDiana, Paredes LarioAlfredo, Sanz-YagüeAlmudena, Serrano BermúdezGala, Soler LópezBegoña, Sánchez MauriñoPedro, Togores TorresPilar

Paper Details 
Original Abstract of the Article :
OBJECTIVES: Naloxegol is a peripherally acting µ-opioid receptor antagonist (PAMORA) for treatment of opioid-induced constipation (OIC). The main objective was to analyse the long-term efficacy, quality of life (QOL) and safety of naloxegol in patients with cancer in a real-world study. METHODS: Th...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10715504/

データ提供:米国国立医学図書館(NLM)

Naloxegol: A Beacon of Hope for Opioid-Induced Constipation

Opioid-induced constipation (OIC) can be like a sandstorm in your digestive system, making everyday life feel like a relentless desert trek. Naloxegol, a peripherally acting µ-opioid receptor antagonist (PAMORA), is like a special desert plant that helps to relieve the constipation without affecting the pain-relieving effects of opioids. This research examines the long-term efficacy and safety of naloxegol in patients with cancer who are experiencing OIC. The authors aim to evaluate [主な目的] and assess the long-term impact of naloxegol on quality of life. They found that [主要な発見], suggesting [研究分野における影響].

Naloxegol: A Oasis in the Desert of Constipation

The research suggests that naloxegol can provide long-lasting relief from opioid-induced constipation in patients with cancer. It's like finding a cool oasis in the midst of a harsh desert journey, offering a much-needed respite from the discomfort. This finding is encouraging for patients who rely on opioids for pain management but experience the debilitating effects of constipation. The study also highlights the importance of addressing the overall quality of life in patients with cancer, emphasizing the need for comprehensive care that takes into account both physical and psychological well-being.

Navigating the Desert of Constipation: A Personalized Approach

If you're experiencing opioid-induced constipation, it's vital to discuss your concerns with your healthcare provider. They can help you find the best solutions for managing your symptoms and improving your quality of life. Just as a skilled desert guide knows how to find the best path through the dunes, your healthcare team can help you navigate the challenges of OIC.

Dr.Camel's Conclusion

This research offers a glimmer of hope for patients facing the challenges of opioid-induced constipation. It's like finding a new type of desert plant that can soothe the digestive system and provide relief from a common but often debilitating side effect. The authors provide valuable insights into the long-term efficacy and safety of naloxegol, emphasizing its potential to improve the lives of patients with cancer.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-14
Further Info :

Pubmed ID

33707299

DOI: Digital Object Identifier

PMC10715504

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PICO Info
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Languages

English

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