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Effects of combination antiretroviral drugs (cART) on hippocampal neuroplasticity in female mice.

Author: AbboussiOualid, DanielsWilliam Mark Uren, MabandlaMusa Vuyisile, SimolaNicola, ZuluSimo Siyanda

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

HIV-associated neurocognitive disorder (HAND) remains a concern despite combination antiretroviral therapy (cART). This study investigated the long-term effects of cART on cognitive function, oxidative damage, autophagy, and neuroplasticity in mice. cART exposure led to impaired spatial learning, increased oxidative damage, and altered autophagy and neuroplasticity in the hippocampus. These findings support the potential neurotoxicity of cART and its role in HAND.
Paper Details　
Original Abstract of the Article :
The incidence of HIV-associated neurocognitive disorder (HAND) continues despite the introduction of combination antiretroviral drugs (cART). Several studies have reported the neurotoxicity of individual antiretroviral drugs (monotherapy), while the common approach for HIV treatment is through cART....See full text at original site
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引用元：
https://doi.org/10.1007/s13365-021-00967-z

データ提供：米国国立医学図書館（NLM）

The Impact of Antiretroviral Drugs on Brain Health: A Journey into the Complexities of HIV

This study delves into the effects of combination antiretroviral drugs (cART), a standard treatment for HIV, on brain health, specifically exploring their impact on hippocampal neuroplasticity. Imagine a camel caravan crossing a vast desert, where the journey can impact the camels' overall health and well-being. cART is like a vital resource, helping to control the disease but potentially having unforeseen consequences on the camels' brains.

The Brain's Resilience: Examining the Effects of cART on Hippocampal Function

The study investigates the potential neurotoxicity of cART on the hippocampus, a brain region crucial for learning and memory. Researchers found that long-term exposure to cART could lead to cognitive impairment, oxidative damage, and alterations in neuroplasticity. Think of the hippocampus as a vital oasis in the desert, providing nourishment and support for the camels' journey. cART, while essential for managing HIV, might have unintended consequences on this vital region.

Navigating the Challenges of HIV Treatment

This study highlights the complex challenges associated with HIV treatment. It underscores the importance of continued research to understand the long-term effects of cART on brain health and develop strategies to mitigate any potential neurotoxicity. It's like a caravan carefully navigating a treacherous desert, seeking ways to protect its members from potential dangers while ensuring their continued well-being.

Dr. Camel's Conclusion

This study reminds us that the journey through HIV treatment is not without its challenges. It's like a camel caravan venturing into a mysterious desert, where the terrain can be unpredictable and the journey can be fraught with complexities. It emphasizes the need for vigilance and continued research to ensure the best possible outcomes for those living with HIV.

Date :
  1. Date Completed 2021-12-06
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

33710598

DOI: Digital Object Identifier

10.1007/s13365-021-00967-z

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Languages

English

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