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A Focused Review of the Metabolic Side-Effects of Clozapine.

Author: BarrAlasdair M, HonerWilliam G, KimDavid D, PanenkaWilliam J, ProcyshynRic M, YuenJessica W Y

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Clozapine is the most effective treatment for treatment-resistant psychosis but is associated with significant metabolic side effects, including glucose and lipid dysregulation. This review discusses the underlying mechanisms of these side effects and treatment options.
Paper Details　
Original Abstract of the Article :
The second generation antipsychotic drug clozapine represents the most effective pharmacotherapy for treatment-resistant psychosis. It is also associated with low rates of extrapyramidal symptoms and hyperprolactinemia compared to other antipsychotic drugs. However, clozapine tends to be underutiliz...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947876/

データ提供：米国国立医学図書館（NLM）

Clozapine: A Powerful Antipsychotic with Metabolic Side Effects

This study focuses on the metabolic side effects associated with clozapine, a second-generation antipsychotic drug known for its effectiveness in treating treatment-resistant psychosis. While clozapine offers a valuable treatment option, it's also known for a number of metabolic side effects, including dysregulation of glucose, insulin, plasma lipids, and body fat. The researchers conducted a review of key studies to understand the impact of clozapine on metabolic health, aiming to identify the underlying mechanisms and potential treatment options.

Understanding Clozapine's Metabolic Impact

The review reveals that clozapine can significantly increase the risk of metabolic syndrome in patients, potentially leading to type 2 diabetes mellitus and cardiovascular disease. The study highlights the need for careful monitoring and management of metabolic parameters in patients taking clozapine. It also emphasizes the importance of further research to better understand the underlying physiological mechanisms behind clozapine's metabolic effects.

Navigating Clozapine's Metabolic Side Effects

The potential for metabolic side effects with clozapine presents a challenge for both patients and healthcare providers. It's important to weigh the benefits of clozapine against these potential risks, carefully monitoring patients for any metabolic changes. Regular blood sugar testing, lipid profile monitoring, and lifestyle modifications can help mitigate these risks. It's also important to consult with a healthcare professional to discuss the best course of action for managing these potential side effects.

Dr.Camel's Conclusion

This research delves into the complex interplay between clozapine, a powerful antipsychotic, and metabolic health, highlighting the importance of careful monitoring and management of metabolic parameters in patients taking this medication. The study's findings serve as a reminder that even with effective medications, it's essential to be vigilant about potential side effects and take proactive steps to manage them. It's like navigating a vast desert of metabolic risks, where careful planning and understanding are crucial for maintaining overall health and well-being.

Date :
  1. Date Completed 2021-12-20
  2. Date Revised 2021-12-20
Further Info :

Pubmed ID

33716966

DOI: Digital Object Identifier

PMC7947876

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in preparation
Languages

English

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