Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China: focus on the safety.

Author: BaiDa-Peng, CaiCui, CaiQing-Shan, ChenWei, ChenXiao-Hong, ChenYu, ChengLi-Li, DuJuan, FanLin, GaoJing-Tao, GaoMeng-Qiu, GengShu-Jun, GuanWen-Long, JinLong, LiGuo-Bao, LiMing-Wu, LiTong-Xia, LiXin-Jie, LiuYu-Hong, MartinezLeonardo, MiaoYan-Fang, NingYu-Jia, PeiYi, ShiJi-Chan, ShuWei, SunYu-Xian, TangPei-Jun, TengFei, WangHua, WangJian-Yun, WuGui-Hui, WuQian-Hong, XieLi, XieShi-Heng, XiongYu, XuLin, YanXiao-Feng, YangGuo-Li, ZengYi, ZhangLi-Jie, ZhouYun, ZhuoMa, ZongPei-Lan

Paper Details 
Original Abstract of the Article :
World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis (DR-TB) should develop and implement a system for active pharmacovigilance that allows for detection, reporting and management of adverse events. The aim of the study is to...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977294/

データ提供:米国国立医学図書館(NLM)

Bedaquiline-Containing Regimens for Pulmonary Multidrug-Resistant Tuberculosis

Tuberculosis (TB), a disease that has plagued humanity for centuries, continues to pose a significant threat to global health. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of TB has added another layer of complexity to this fight. This study focuses on the use of bedaquiline-containing regimens in patients with pulmonary MDR/XDR-TB in China. Researchers sought to evaluate the frequency and severity of adverse events associated with this treatment regimen, utilizing an active drug safety monitoring system. The study provides valuable insights into the safety profile of bedaquiline-containing regimens, contributing to the ongoing efforts to combat drug-resistant TB, a challenge as formidable as navigating a treacherous sandstorm.

Bedaquiline: Navigating the Safety Landscape of Drug-Resistant TB Treatment

The study found that bedaquiline-containing regimens, while effective in treating MDR/XDR-TB, are not without their risks. Adverse events, though manageable, are a concern. The findings highlight the importance of continuous monitoring and careful management of patients receiving this treatment. It's like navigating a sandstorm – you need to be aware of the potential dangers and have a plan to mitigate them.

A Call for Vigilance in TB Treatment

This research emphasizes the critical need for vigilance in the treatment of drug-resistant TB. The use of bedaquiline-containing regimens requires careful monitoring and management to ensure patient safety. While offering hope for patients with MDR/XDR-TB, it's crucial to understand the potential side effects and take appropriate measures to address them. It's like traversing a desert – you need to pack enough water and provisions to ensure a safe journey.

Dr.Camel's Conclusion

Bedaquiline-containing regimens offer a promising treatment option for patients with drug-resistant TB. However, the study underscores the importance of active pharmacovigilance and careful management to mitigate potential risks. It's a reminder that even in the face of advancement, we must remain vigilant and adaptable when dealing with this complex and challenging disease. The fight against TB is a long and arduous journey, but with constant research and careful monitoring, we can continue to make progress.

Date :
  1. Date Completed 2021-08-18
  2. Date Revised 2021-08-18
Further Info :

Pubmed ID

33736710

DOI: Digital Object Identifier

PMC7977294

Related Literature

SNS
PICO Info
in preparation
Languages

English

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