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Safety and efficacy of methotrexate (0.3 mg/kg/week) versus a combination of methotrexate (0.15 mg/kg/week) with cyclosporine (2.5 mg/kg/day) in chronic plaque psoriasis: A randomised non-blinded controlled trial.

Author: SinghSatyendra Kumar, SingnarpiSermili Rini

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Psoriasis is a chronic skin condition that can't be cured. While methotrexate (MTX) and cyclosporine (CsA) are used to treat psoriasis, they're usually given alone because there's concern about combining them due to potential side effects. This study will investigate whether combining these medications is effective for treating psoriasis.
Paper Details　
Original Abstract of the Article :
Psoriasis is a chronic, inflammatory, relapsing and remitting disease with no cure till date. There is a paucity of trials using a combination of methotrexate (MTX) and cyclosporine (CsA) in chronic plaque psoriasis, due to fear of added toxicity, although they are time tested treatment options for ...See full text at original site
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引用元：
https://doi.org/10.25259/IJDVL_613_19

データ提供：米国国立医学図書館（NLM）

Treating Chronic Plaque Psoriasis: Exploring a Combination Therapy

Chronic plaque psoriasis is a challenging skin condition requiring effective treatment options. This study investigates the safety and efficacy of a combination therapy using methotrexate (MTX) and cyclosporine (CsA) in patients with chronic plaque psoriasis. The authors conduct a randomized controlled trial comparing the combination therapy with monotherapy using MTX. Their findings provide valuable insights into the potential benefits and risks of combining MTX and CsA in the management of chronic plaque psoriasis.

MTX and CsA Combination: A Potential Treatment Option for Chronic Plaque Psoriasis

This study suggests that combining MTX and CsA may offer a viable treatment option for patients with chronic plaque psoriasis. While the combination therapy showed a trend towards improved outcomes, further research is needed to confirm its efficacy and safety. The study underscores the importance of carefully monitoring patients receiving this combination therapy, ensuring that the potential benefits outweigh the potential risks.

Navigating the Complexity of Psoriasis Treatment

This research highlights the complexities of treating chronic plaque psoriasis, emphasizing the need for a multifaceted approach. The study explores the potential of a combination therapy involving MTX and CsA, but also acknowledges the need for individualized treatment plans and careful patient monitoring. This reflects the ongoing quest for better treatment options for psoriasis, striving for improved outcomes and a better quality of life for patients.

Dr.Camel's Conclusion

Just like a camel adapts to the harsh desert environment, psoriasis patients need tailored treatment strategies to manage their condition. This research explores the potential of a combination therapy, highlighting the ongoing efforts to find effective and safe solutions for chronic plaque psoriasis.

Date :
  1. Date Completed 2021-11-01
  2. Date Revised 2022-07-27
Further Info :

Pubmed ID

33769732

DOI: Digital Object Identifier

10.25259/IJDVL_613_19

Related Literature

Article Analysis
・Effective treatment of psoriasis
SNS
PICO Info
in preparation
Languages

English

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