Hydroxyurea in children with sickle cell disease in a resource-poor setting: Monitoring and effects of therapy. A practical perspective.

Author: AdebayoInnocent, AdekileAdekunle, ErigbuemIfeanyi, JamesEsther, KumodeEvelyn, Nnebe-AgumaduUche, NnoduObiageli

Paper Details 
Original Abstract of the Article :
BACKGROUND: Although effectiveness of hydroxyurea (HU) in sickle cell disease is well established, unanswered questions persist about its use in African children. We determined real-life issues of acceptability, availability, and monitoring of HU use in Nigeria. METHODS: A retrospective longitudina...See full text at original site
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引用元:
https://doi.org/10.1002/pbc.28969

データ提供:米国国立医学図書館(NLM)

Hydroxyurea in Sickle Cell Disease: A Desert Oasis for Children

Sickle cell disease is like a scorching desert, leaving individuals vulnerable to pain, fatigue, and a variety of complications. This research, published in the field of hematology, explores the use of hydroxyurea (HU) in children with sickle cell disease in a resource-poor setting. The study investigated the real-life challenges of using HU in Nigeria, focusing on issues related to acceptability, availability, and monitoring of treatment. The researchers found that HU was well tolerated and appeared to be effective in reducing pain episodes, hospital admissions, and blood transfusion requirements. Despite challenges in monitoring and adherence, HU treatment was associated with significant improvements in hemoglobin levels, hemoglobin F levels, and mean corpuscular volume.

A Beacon of Hope in the Desert

The findings of this study demonstrate the potential benefits of HU treatment for children with sickle cell disease in resource-limited settings. Despite logistical challenges, HU showed promising results in improving clinical outcomes and improving the quality of life for these patients. It’s like finding a beacon of hope in the vast and unforgiving desert, guiding individuals towards a brighter future.

Navigating the Desert of Sickle Cell Disease

This research highlights the importance of addressing the needs of children with sickle cell disease in resource-limited settings. HU treatment offers a valuable tool for managing the disease and improving patient well-being, but access to affordable medications and consistent monitoring are crucial. It’s like having a well-stocked oasis in the desert, providing the resources and support needed for individuals to navigate the challenges of sickle cell disease.

Dr. Camel's Conclusion

This research underscores the need for accessible and effective treatments for sickle cell disease, especially in resource-limited settings. HU treatment offers a promising avenue for improving the lives of children with this challenging condition. This research is like a caravan traveling through the desert, bringing hope and resources to those in need.

Date :
  1. Date Completed 2021-11-16
  2. Date Revised 2021-11-16
Further Info :

Pubmed ID

33788390

DOI: Digital Object Identifier

10.1002/pbc.28969

Related Literature

SNS
PICO Info
in preparation
Languages

English

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