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Establishment of an analytical method for simultaneous quantitation of CDK4/6 inhibitors, aromatase inhibitors, and an estrogen receptor antagonist in human plasma using LC-ESI-MS/MS.

Author: EbataAkiko, HamanakaYohei, HirasawaTensei, IshidaTakanori, KikuchiMasafumi, MaekawaMasamitsu, ManoNariyasu, OguraJiro, SatoToshihiro, SatoYu, ShigetaKensuke, TadaHiroshi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study describes a simple, highly sensitive, and specific liquid chromatography/electrospray ionization tandem mass spectrometry method for simultaneous quantitation of CDK4/6 inhibitors, aromatase inhibitors, and an estrogen receptor antagonist.
Paper Details　
Original Abstract of the Article :
Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors (palbociclib, abemaciclib, and ribociclib) are used to treat human epithelial growth factor receptor (HER)-2 negative and hormone receptor (HR) positive advanced breast cancer in combination with aromatase inhibitors (letrozole, anastrozole) or an ...See full text at original site
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引用元：
https://doi.org/10.1016/j.jchromb.2021.122655

データ提供：米国国立医学図書館（NLM）

Simultaneous Quantitation of CDK4/6 Inhibitors, Aromatase Inhibitors, and an Estrogen Receptor Antagonist in Human Plasma

The treatment of [breast cancer] has advanced significantly with the development of targeted therapies. This study focuses on [establishing an analytical method for simultaneous quantitation of CDK4/6 inhibitors, aromatase inhibitors, and an estrogen receptor antagonist in human plasma]. The authors aim to [develop a sensitive and reliable method for therapeutic drug monitoring (TDM)] of these drugs, crucial for ensuring both efficacy and safety in patients undergoing treatment.

Precision in Treatment: The Importance of TDM

This research highlights the critical role of [TDM in optimizing cancer treatment]. The authors developed a [highly sensitive and specific liquid chromatography/electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method] for simultaneous quantitation of these drugs in human plasma. This advanced method allows for [accurate monitoring of drug levels], enabling healthcare providers to make [informed decisions about dose adjustments] and minimize potential adverse effects.

Tailored Treatment: A Key to Better Outcomes

This research underscores the importance of [individualized treatment approaches] in cancer care. By providing a [reliable method for TDM], healthcare providers can [tailor treatment regimens] to each patient's unique needs, ensuring optimal outcomes and minimizing the risk of complications.

Dr.Camel's Conclusion

Just as a camel navigates a complex desert landscape, cancer treatment requires a precise and personalized approach. This research provides a valuable tool—a sensitive and reliable method for TDM—to guide healthcare providers in optimizing treatment regimens and ensuring safe and effective outcomes for patients battling this challenging disease.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-05-24
Further Info :

Pubmed ID

33831689

DOI: Digital Object Identifier

10.1016/j.jchromb.2021.122655

SNS
PICO Info
in preparation
Languages

English

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