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<i>In vitro</i> inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6.

Author: AhemadNafees, OngChin Eng, OthmanIekhsan, PalanisamyUma Devi, PanYan, TanBoon Hooi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the inhibitory effect of glucosamine, chondroitin, and diacerein, commonly used natural compounds for treating osteoarthritis, on cytochrome P450 2D6 (CYP2D6), a major hepatic enzyme involved in drug metabolism. The findings aim to provide insights into potential drug-natural product interactions associated with these antiarthritic compounds.
Paper Details　
Original Abstract of the Article :
Glucosamine, chondroitin and diacerein are natural compounds commonly used in treating osteoarthritis. Their concomitant intake may trigger drug-natural product interactions. Cytochrome P450 (CYP) has been implicated in such interactions. Cytochrome P450 2D6 (CYP2D6) is a major hepatic CYP involved ...See full text at original site
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引用元：
https://doi.org/10.1515/dmdi-2020-0182

データ提供：米国国立医学図書館（NLM）

Glucosamine, Chondroitin, and Diacerein: A Potential for Drug Interactions?

The search for effective treatments for osteoarthritis (OA) continues to be a primary focus of medical research. This study examines the potential for drug interactions between glucosamine, chondroitin, and diacerein, three commonly used natural compounds for treating OA. The researchers investigated the inhibitory effects of these compounds on CYP2D6, a major enzyme involved in drug metabolism in the liver.

Navigating the Desert of Drug Interactions

This study sheds light on the potential for drug interactions between commonly used natural compounds and prescription medications. The researchers found that glucosamine, chondroitin, and diacerein can inhibit CYP2D6 activity, which could lead to altered drug metabolism and potentially affect the efficacy and safety of other medications. This finding underscores the importance of considering potential interactions between natural products and prescription drugs.

The Importance of Open Communication and Informed Decision-Making

This study emphasizes the importance of open communication between patients and their healthcare providers about all medications, including natural products. It's crucial for patients to disclose all supplements and medications they are taking to ensure that their healthcare providers are aware of potential drug interactions. This can help prevent adverse events and ensure that patients receive safe and effective treatment.

Dr.Camel's Conclusion

This study reminds us that even in the vast desert of medical knowledge, there are always hidden dangers to be aware of. The potential for drug interactions between natural products and prescription medications underscores the importance of open communication and informed decision-making. By staying vigilant and seeking guidance from healthcare professionals, we can navigate the complexities of drug therapy and ensure that patients receive the best possible care.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-04-08
Further Info :

Pubmed ID

33831979

DOI: Digital Object Identifier

10.1515/dmdi-2020-0182

Related Literature

Article Analysis
・Effective treatment of chondroitin
SNS
PICO Info
in preparation
Languages

English

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