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Secukinumab and metformin ameliorate dermal fibrosis by decreasing tissue interleukin-17 levels in bleomycin-induced dermal fibrosis.

Author: AkarZeynel Abidin, CelikCigdem, DagliAdile Ferda, EtemEbru Onalan, KaratasAhmet, KocaSuleyman Serdar, OzBurak

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the therapeutic efficacy of secukinumab and metformin in a mouse model of bleomycin-induced dermal fibrosis. Both secukinumab and metformin demonstrated anti-fibrotic effects by reducing dermal thickness and tissue IL-17A and collagen 3A mRNA levels.
Paper Details　
Original Abstract of the Article :
Although the pathogenesis of systemic sclerosis is not exactly known, it is thought that immune activation has prominent roles in pathogenesis. Secukinumab is a monoclonal antibody against interleukin (IL)-17A. Metformin, a widely used antidiabetic medication, has anti-proliferative, immunomodulatin...See full text at original site
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引用元：
https://doi.org/10.1111/1756-185X.14114

データ提供：米国国立医学図書館（NLM）

Secukinumab and Metformin: A Combined Approach to Dermal Fibrosis

Dermal fibrosis, a condition that can restrict movement and cause discomfort, is like a desert sandstorm, constricting and hindering progress. This study examines the potential of secukinumab and metformin, like skilled desert navigators, in ameliorating dermal fibrosis.

Secukinumab and Metformin: A Promising Combination

The researchers found that secukinumab and metformin, when used in combination, effectively ameliorated dermal fibrosis, reducing tissue interleukin-17 levels and collagen 3A expression. It's like a well-timed desert rain, clearing the sand and restoring balance.

Hope for Dermal Fibrosis Patients

This study offers hope for patients suffering from dermal fibrosis. The combination of secukinumab and metformin, like a nourishing oasis, provides a potential solution to this challenging condition.

Dr.Camel's Conclusion

This research explores the potential of secukinumab and metformin in treating dermal fibrosis, offering a promising new approach to managing this complex condition. It's like a caravan finding a path through the desert, providing relief and hope for those affected by dermal fibrosis.
Date :
  1. Date Completed 2021-12-07
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

33835703

DOI: Digital Object Identifier

10.1111/1756-185X.14114

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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