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Protective effects of prucalopride in MPTP-induced Parkinson's disease mice: Neurochemistry, motor function and gut barrier.

Author: CuiChun, HongHui, HuangShu-Bing, JiaXue-Bing, QiaoChen-Meng, ShenYan-Qin, ShiYun, WuJi, YaoLi, ZhaoWei-Jiang, ZhouYu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Prucalopride, a 5-HT4 receptor agonist, was found to improve motor deficits in a mouse model of Parkinson's disease. The drug also attenuated dopamine loss, improved intestinal barrier impairment, and increased IL-6 release.
Paper Details　
Original Abstract of the Article :
Evidence suggests constipation precedes motor dysfunction and is the most common gastrointestinal symptom in Parkinson's disease (PD). 5-HT4 receptor (5-HT4R) agonist prucalopride has been approved to treat chronic constipation. Here, we reported intraperitoneal injection of prucalopride for 7 days ...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbrc.2021.03.109

データ提供：米国国立医学図書館（NLM）

Prucalopride for Parkinson's Disease: A Potential Oasis in the Desert of Symptoms

This study explores the potential benefits of prucalopride, a medication typically used for chronic constipation, in the management of Parkinson's disease. Researchers investigated the effects of prucalopride on dopamine levels, motor function, and gut barrier integrity in mice with Parkinson's-like symptoms.

A Serendipitous Discovery in the Desert of Parkinson's Disease

The study demonstrated that prucalopride administration improved dopamine levels, reduced motor deficits, and ameliorated intestinal barrier impairment in these mice. These findings suggest that prucalopride may offer a multifaceted approach to managing some of the challenges associated with Parkinson's disease.

From Gut Health to Brain Health: A Promising Connection

This study underscores the intriguing connection between gut health and brain health. The potential of prucalopride to benefit both intestinal function and motor symptoms in Parkinson's disease suggests promising avenues for future research and treatment strategies.

Dr.Camel's Conclusion

This research reminds us that the desert of medical knowledge is full of hidden oases waiting to be discovered. The potential of prucalopride for Parkinson's disease is an exciting development, illustrating the importance of exploring innovative approaches to managing complex conditions.

Date :
  1. Date Completed 2021-07-20
  2. Date Revised 2021-07-20
Further Info :

Pubmed ID

33836343

DOI: Digital Object Identifier

10.1016/j.bbrc.2021.03.109

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Languages

English

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