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Fatal adverse drug reactions: A worldwide perspective in the World Health Organization pharmacovigilance database.

Author: BagheriHaleh, DurrieuGeneviève, LafaurieMargaux, MontastrucFrançois, MontastrucJean-Louis, SommetAgnès, de CanecaudeClaire

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Antineoplastic/immunomodulating drugs were the most frequently involved drug class in fatal ADRs, and the risk was higher in males, in the Americas, and in patients ≥65 years.
Paper Details　
Original Abstract of the Article :
AIMS: Adverse drug reactions (ADRs) are important causes of death. However, the main involved drugs are relatively unknown. The present study was performed to characterise death-related drugs recorded in a large pharmacovigilance database during the last 10 years. METHODS: A retrospective analysis ...See full text at original site
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引用元：
https://doi.org/10.1111/bcp.14851

データ提供：米国国立医学図書館（NLM）

Fatal Adverse Drug Reactions: A Worldwide Perspective in the World Health Organization Pharmacovigilance Database

This study explores the global landscape of [pharmacovigilance] and investigates the incidence and characteristics of fatal adverse drug reactions (ADRs) recorded in the World Health Organization's pharmacovigilance database. The study analyzes data from a 10-year period (2010-2019) and identifies the most frequently involved drug classes and individual drugs. The study found that fatal ADRs were reported mainly in patients older than 75 years, with antineoplastic/immunomodulating drugs, nervous system drugs, and cardiac drugs being the most frequently implicated drug classes. The researchers also observed significant differences in the reporting of fatal ADRs according to sex, age, continents, and countries.

Understanding the Risks of Medications

This study provides a comprehensive overview of fatal ADRs reported worldwide. The findings highlight the importance of understanding the risks and benefits of medications, particularly in older adults. The study also underscores the need for careful monitoring and reporting of ADRs to improve patient safety.

Ensuring Patient Safety in a Globalized World

This study highlights the importance of pharmacovigilance in a globalized world. By analyzing data from a large international database, the study provides valuable insights into the incidence and characteristics of fatal ADRs, which can inform efforts to improve patient safety worldwide.

Dr.Camel's Conclusion

The desert of healthcare can be treacherous, full of unexpected dunes and hidden dangers. This research provides a global map of the risks associated with medications. By understanding these risks, we can navigate the landscape of healthcare more safely and effectively.
Date :
  1. Date Completed 2021-12-07
  2. Date Revised 2021-12-14
Further Info :

Pubmed ID

33837554

DOI: Digital Object Identifier

10.1111/bcp.14851

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