Paper Details

  1. Home
  2. Paper Details

Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target.

Author: CarusoDonatella, ContiniAlessandro, Di DomizioAlessandro, DiviccaroSilvia, FalvoEva, GiattiSilvia, MelcangiRoberto Cosimo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Finasteride, a widely used drug for androgen-dependent conditions, may cause sexual, psychological, and physical side effects. This study suggests that finasteride may inhibit phenylethanolamine N-methyltransferase (PNMT), the enzyme responsible for epinephrine synthesis, which may contribute to the side effects.
Paper Details　
Original Abstract of the Article :
Finasteride, a 5-alpha reductase (5α-R) inhibitor, is a widely used drug for treating androgen-dependent conditions. However, its use is associated with sexual, psychological, and physical complaints, suggesting that other mechanisms, in addition to 5α-R inhibition, may be involved. Here, ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154553/

データ提供：米国国立医学図書館（NLM）

Unmasking Finasteride’s Hidden Actions: A Proteome-Wide Search for Off-Target Effects

This research delves into the off-target effects of finasteride, a widely used drug for treating androgen-dependent conditions. Using a multidisciplinary approach, including computational modeling, molecular dynamics simulations, and in vitro and in vivo assays, the study identified a potential novel off-target interaction between finasteride and phenylethanolamine N-methyltransferase (PNMT), the enzyme responsible for epinephrine production. The findings suggest that finasteride's binding to PNMT may contribute to some of the side effects associated with finasteride treatment, including sexual and psychological complaints.

A Deeper Look at Finasteride’s Actions

The study sheds light on the complex actions of finasteride, revealing a potential off-target effect that may contribute to its side effects. The researchers' findings provide valuable insights into the drug’s mechanisms of action and highlight the importance of considering potential off-target effects in drug development and patient care.

Navigating the Shifting Sands of Drug Development

The desert of drug development is vast and challenging, with researchers constantly seeking to understand the complexities of drug interactions. This study, like a skilled explorer navigating this terrain, unveils a potential off-target effect of finasteride, providing valuable insights for future drug development and patient care. The findings underscore the importance of comprehensive research and ongoing monitoring to ensure drug safety and optimize treatment outcomes.

Dr.Camel's Conclusion

This study, like a camel caravan traversing a vast desert, reveals the intricate world of drug interactions, highlighting the potential for off-target effects. The researchers' findings underscore the importance of comprehensive research and ongoing monitoring to ensure drug safety and optimize treatment outcomes.
Date :
  1. Date Completed 2021-06-16
  2. Date Revised 2021-06-16
Further Info :

Pubmed ID

33843213

DOI: Digital Object Identifier

PMC8154553

Related Literature

Article Analysis
・Side Effects of finasteride
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.