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Hypercalcemia associated with the interaction between all trans retinoic acid and posaconazole in an acute promyelocytic leukemia case.
Author: Afacan OzturkHacer Berna, AkyolPınar, AlbayrakMurat, MalkanUmit Yavuz, MaralSenem, Reis ArasMerih, TigliogluMesut, YilmazFatma
Original Abstract of the Article :
All-trans retinoic acid (ATRA) is a physiological metabolite of vitamin A and it is used for the treatment of acute promyelocytic leukemia (APL). Hypercalcemia is a rare side effect of ATRA and it may be potentiated after interaction of ATRA with azole group antifungals. Herein, we have reported an ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1177/10781552211007889
データ提供:米国国立医学図書館(NLM)
A Case of Hypercalcemia: Untangling the Interplay of Drugs
The treatment of [acute promyelocytic leukemia] often involves a delicate balance of medications. This case study explores the potential interaction between [all-trans retinoic acid (ATRA)] and [posaconazole], two medications commonly used in the treatment of APL. The study reports a case of [hypercalcemia] that was linked to the interaction between these drugs.
A Glimpse into Drug Interactions
This case study underscores the importance of careful consideration of drug interactions, especially in patients receiving complex treatment regimens. Like a mirage in the desert, drug interactions can sometimes appear unexpected and can have significant consequences for patients. This research highlights the need for ongoing vigilance and careful monitoring of patients receiving multiple medications.
The Importance of Informed Decision-Making
This case study highlights the importance of thorough medical history, careful drug selection, and close patient monitoring to minimize the risk of drug interactions. It emphasizes the need for a multidisciplinary approach to patient care, involving physicians, pharmacists, and other healthcare professionals who are well-versed in the potential risks and benefits of various medications.
Dr. Camel's Conclusion
This case study serves as a valuable reminder of the complex interplay of factors that can influence drug effectiveness and safety. Just as a camel must carefully navigate the shifting sands of the desert, healthcare professionals must be vigilant in understanding and managing potential drug interactions.
Date :
- Date Completed 2022-02-08
- Date Revised 2022-05-01
Further Info :
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