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PARP Inhibitor in Platinum-Resistant Ovarian Cancer: Single-Center Real-World Experience.
Author: AgarwalAmit, BaghmarSaphalta, DodagoudarChandragouda, KhuranaAseem, KumarGuresh, QureshiSuhail, VaibhavVikas
Original Abstract of the Article :
Label="PURPOSE">Poly (ADP-ribose) polymerase inhibitors (PARPi) have proven efficacy in treatment of BReast CAncer (<i>BRCA</i>) gene mutation-positive platinum-sensitive ovarian cancers. There is paucity of data for their role in platinum-resistant ovarian cancer (PROC). We report here retrospectiv...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162970/
データ提供:米国国立医学図書館(NLM)
PARP Inhibitors: A New Hope for Platinum-Resistant Ovarian Cancer?
Ovarian cancer, a formidable foe in the world of oncology, can be particularly challenging to treat when it becomes resistant to platinum-based chemotherapy. PARP inhibitors, a novel class of drugs that target the PARP enzyme, have shown promise in treating BRCA gene mutation-positive platinum-sensitive ovarian cancers. However, their role in platinum-resistant ovarian cancer (PROC) remains largely unexplored.
This single-center real-world study provides valuable insights into the efficacy of PARP inhibitors in a group of patients, including those with PROC. The authors present their retrospective analysis of patient outcomes, offering a glimpse into the potential of PARP inhibitors in this difficult-to-treat cancer.
Expanding the Arsenal Against Ovarian Cancer
The findings of this study suggest that PARP inhibitors may hold potential as a new weapon in the fight against PROC. Further research is needed to confirm their efficacy and determine their optimal role in treatment regimens.
Dr. Camel's Conclusion
Imagine a desert battle, where the enemy has become resistant to the usual weapons. The need for innovative strategies is paramount. This study offers a glimmer of hope, like a desert flower blossoming amidst the sand, suggesting that PARP inhibitors may be a valuable addition to the arsenal for combating platinum-resistant ovarian cancer.
Date :
- Date Completed 2021-08-05
- Date Revised 2023-11-11
Further Info :
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English
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