PARP Inhibitor in Platinum-Resistant Ovarian Cancer: Single-Center Real-World Experience.

Author: AgarwalAmit, BaghmarSaphalta, DodagoudarChandragouda, KhuranaAseem, KumarGuresh, QureshiSuhail, VaibhavVikas

Paper Details 
Original Abstract of the Article :
Label="PURPOSE">Poly (ADP-ribose) polymerase inhibitors (PARPi) have proven efficacy in treatment of BReast CAncer (<i>BRCA</i>) gene mutation-positive platinum-sensitive ovarian cancers. There is paucity of data for their role in platinum-resistant ovarian cancer (PROC). We report here retrospectiv...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162970/

データ提供:米国国立医学図書館(NLM)

PARP Inhibitors: A New Hope for Platinum-Resistant Ovarian Cancer?

Ovarian cancer, a formidable foe in the world of oncology, can be particularly challenging to treat when it becomes resistant to platinum-based chemotherapy. PARP inhibitors, a novel class of drugs that target the PARP enzyme, have shown promise in treating BRCA gene mutation-positive platinum-sensitive ovarian cancers. However, their role in platinum-resistant ovarian cancer (PROC) remains largely unexplored.

This single-center real-world study provides valuable insights into the efficacy of PARP inhibitors in a group of patients, including those with PROC. The authors present their retrospective analysis of patient outcomes, offering a glimpse into the potential of PARP inhibitors in this difficult-to-treat cancer.

Expanding the Arsenal Against Ovarian Cancer

The findings of this study suggest that PARP inhibitors may hold potential as a new weapon in the fight against PROC. Further research is needed to confirm their efficacy and determine their optimal role in treatment regimens.

Dr. Camel's Conclusion

Imagine a desert battle, where the enemy has become resistant to the usual weapons. The need for innovative strategies is paramount. This study offers a glimmer of hope, like a desert flower blossoming amidst the sand, suggesting that PARP inhibitors may be a valuable addition to the arsenal for combating platinum-resistant ovarian cancer.

Date :
  1. Date Completed 2021-08-05
  2. Date Revised 2023-11-11
Further Info :

Pubmed ID

33852339

DOI: Digital Object Identifier

PMC8162970

Related Literature

SNS
PICO Info
in preparation
Languages

English

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