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Within-subject, double-blinded, randomized, and placebo-controlled evaluation of the combined effects of the cannabinoid dronabinol and the opioid hydromorphone in a human laboratory pain model.

Author: BergeriaCecilia L, CampbellClaudia M, DunnKelly E, HuhnAndrew S, MunChung Jung, SpeedTraci J, VandreyRyan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study investigated the analgesic, abuse liability, and cognitive effects of combining hydromorphone with oral delta-9-tetrahydrocannabinol (THC; dronabinol) in healthy individuals. Only the combination of hydromorphone and low-dose dronabinol (2.5 mg) modestly enhanced analgesia, while higher doses (5 and 10 mg) increased the risk of abuse and adverse events. These findings suggest potential benefits of low-dose THC for opioid-sparing strategies but emphasize the need for caution with higher doses.
Paper Details　
Original Abstract of the Article :
This Phase II study evaluated analgesia, abuse liability, and cognitive performance of hydromorphone and oral delta-9-tetrahydrocannabinol (THC; dronabinol) using a within-subject, double-blind, randomized, placebo-controlled, human laboratory trial. Healthy adults (N = 29) with no history of drug u...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055479/

データ提供：米国国立医学図書館（NLM）

Dronabinol and Hydromorphone: Exploring the Potential of a New Pain Relief Duo

The search for effective pain relief is a never-ending quest. This research investigates the combined effects of dronabinol (a cannabinoid) and hydromorphone (an opioid) in a human laboratory pain model. It's like exploring a new desert oasis, seeking a combination of natural resources to provide sustenance and relief.

A Complex Interaction: Dronabinol and Hydromorphone

The study found that the combination of dronabinol and hydromorphone had varying effects on analgesia and abuse liability. While a low dose of dronabinol (2.5mg) seemed to enhance hydromorphone's analgesic effects, higher doses increased the risk of abuse and adverse effects. It's like blending different types of sand to create a unique mixture, but finding the right proportions is crucial for stability.

Navigating Pain Management with Caution

This research highlights the complex interactions between cannabinoids and opioids, emphasizing the importance of individualized treatment approaches and careful monitoring. It's like learning to navigate a desert with different types of terrain, requiring flexibility and adaptability. Further research is needed to optimize the use of these drugs for pain relief, ensuring a safe and effective journey.

Dr.Camel's Conclusion

This research delves into the potential of combining cannabinoids and opioids for pain management. It highlights the importance of understanding the complex interactions between these drugs and the need for individualized treatment approaches. It's a reminder that the quest for effective pain relief requires a careful and nuanced approach, considering both potential benefits and risks. It's like navigating a desert with a mix of treacherous sand dunes and lush oases, requiring a steady hand and a discerning eye.

Date :
  1. Date Completed 2021-06-28
  2. Date Revised 2023-01-31
Further Info :

Pubmed ID

33879842

DOI: Digital Object Identifier

PMC8055479

Related Literature

Article Analysis
・Effects of hydromorphone・Effects of dronabinol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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