Evolving role of entrectinib in treatment of <i>NTRK</i>-positive tumors.

Author: BuiNam Q, ChawlaNeal, SeetharamMahesh

Paper Details 
Original Abstract of the Article :
Targeted therapy has shown to be a very effective treatment in tumors with specific genomic drivers. Trk&#160;has proven to be one such target. Efforts to target the Trk fusion with specific inhibitors have shown remarkable responses in a tumor agnostic fashion, with responses seen even in patients ...See full text at original site
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引用元:
https://doi.org/10.2217/fon-2020-0936

データ提供:米国国立医学図書館(NLM)

Entrectinib: A Promising New Weapon in the Fight Against NTRK-Positive Tumors

Targeted therapy has emerged as a powerful weapon in the fight against cancer, allowing clinicians to precisely target specific genetic mutations that drive tumor growth. This research focuses on the role of entrectinib, a first-generation Trk inhibitor, in the treatment of NTRK-positive tumors. The authors reviewed the results of early-phase clinical trials demonstrating the impressive activity of entrectinib in patients with NTRK fusion-positive solid tumors and ROS1-positive non-small-cell lung cancers. Entrectinib has shown promising results in treating brain metastases and is generally well-tolerated, offering a new hope for patients with these challenging cancers.

Entrectinib: A Targeted Approach to Cancer Treatment

The study's findings suggest that entrectinib is a valuable addition to the arsenal of targeted therapies available for patients with NTRK-positive tumors. This targeted approach offers the potential for greater effectiveness while minimizing the side effects of traditional chemotherapy. It's like using a precisely honed tool to target a specific area in the desert, rather than relying on a broad-spectrum approach that can cause collateral damage.

A New Horizon in Cancer Treatment

This research highlights the transformative potential of targeted therapies in the fight against cancer. Entrectinib represents a significant advancement, offering a new horizon for patients with NTRK-positive tumors. It's like discovering a new oasis in the desert of cancer research, providing much-needed relief and hope for patients facing this challenging disease.

Dr. Camel's Conclusion

This research showcases the promising potential of entrectinib as a targeted therapy for NTRK-positive tumors. The study's findings offer a glimmer of hope for patients battling these challenging cancers, highlighting the ongoing progress in the fight against cancer. This research is a reminder that the desert of cancer research is constantly evolving, with new discoveries emerging to improve the lives of patients.
Date :
  1. Date Completed 2021-12-20
  2. Date Revised 2021-12-20
Further Info :

Pubmed ID

33896226

DOI: Digital Object Identifier

10.2217/fon-2020-0936

Related Literature

SNS
PICO Info
in preparation
Languages

English

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