Pharmacokinetics and safety of rucaparib in patients with advanced solid tumors and hepatic impairment.

Author: BeltmanJeri, CentkowskiPiotr, DrewYvette, DziadziuszkoRafal, GrechkoNikolay, HabeckJenn, LiaoMingxiang, NashEileen, RamlauRodryg, SkarbovaViera, Tomaszewska-KiecanaMonika, XiaoJim, ZemanovaMilada

Paper Details 
Original Abstract of the Article :
The poly(ADP-ribose) polymerase inhibitor rucaparib is approved for the treatment of patients with recurrent ovarian and metastatic castration-resistant prostate cancer; however, limited data are available on its use in patients with hepatic dysfunction. This study investigated whether hepatic impai...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236452/

データ提供:米国国立医学図書館(NLM)

Rucaparib in Patients with Hepatic Impairment

Rucaparib, a medication used to treat certain types of cancer, is an effective therapy, but its use in patients with liver dysfunction is not fully understood. This research explores the pharmacokinetics, safety, and tolerability of rucaparib in patients with hepatic impairment. The study aims to determine whether liver function affects the way the body processes rucaparib, potentially influencing its effectiveness and side effect profile.

Hepatic Impairment and Rucaparib Pharmacokinetics

The study found that hepatic impairment did not significantly affect the pharmacokinetics, safety, and tolerability of rucaparib. The researchers observed that rucaparib was well-tolerated in patients with hepatic impairment, suggesting that it may be a safe and effective treatment option for individuals with liver dysfunction. However, the study recommends careful monitoring for potential side effects and dose adjustments based on individual patient characteristics.

Expanding Treatment Options for Cancer Patients

This research provides valuable insights into the use of rucaparib in patients with hepatic impairment. The study's findings suggest that rucaparib can be a viable treatment option for individuals with liver dysfunction, expanding the range of available therapies for cancer patients with this common comorbidity. The study emphasizes the need for ongoing research to further investigate the use of rucaparib in patients with hepatic impairment and to optimize treatment strategies for this patient population.

Dr.Camel's Conclusion

Just like a camel can endure the harsh desert climate, rucaparib may be able to withstand the challenges of hepatic impairment. This research provides valuable insights into the safety and effectiveness of rucaparib in patients with liver dysfunction, offering a potential treatment option for those facing this challenging condition. The study reminds us that even in the face of complex medical conditions, like hepatic impairment, we can find solutions and offer hope to those facing the challenges of cancer.

Date :
  1. Date Completed 2021-09-17
  2. Date Revised 2023-11-07
Further Info :

Pubmed ID

33909097

DOI: Digital Object Identifier

PMC8236452

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Languages

English

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