Paper Details
- Home
- Paper Details
Pharmacokinetics and safety of rucaparib in patients with advanced solid tumors and hepatic impairment.
Author: BeltmanJeri, CentkowskiPiotr, DrewYvette, DziadziuszkoRafal, GrechkoNikolay, HabeckJenn, LiaoMingxiang, NashEileen, RamlauRodryg, SkarbovaViera, Tomaszewska-KiecanaMonika, XiaoJim, ZemanovaMilada
Original Abstract of the Article :
The poly(ADP-ribose) polymerase inhibitor rucaparib is approved for the treatment of patients with recurrent ovarian and metastatic castration-resistant prostate cancer; however, limited data are available on its use in patients with hepatic dysfunction. This study investigated whether hepatic impai...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236452/
データ提供:米国国立医学図書館(NLM)
Rucaparib in Patients with Hepatic Impairment
Rucaparib, a medication used to treat certain types of cancer, is an effective therapy, but its use in patients with liver dysfunction is not fully understood. This research explores the pharmacokinetics, safety, and tolerability of rucaparib in patients with hepatic impairment. The study aims to determine whether liver function affects the way the body processes rucaparib, potentially influencing its effectiveness and side effect profile.
Hepatic Impairment and Rucaparib Pharmacokinetics
The study found that hepatic impairment did not significantly affect the pharmacokinetics, safety, and tolerability of rucaparib. The researchers observed that rucaparib was well-tolerated in patients with hepatic impairment, suggesting that it may be a safe and effective treatment option for individuals with liver dysfunction. However, the study recommends careful monitoring for potential side effects and dose adjustments based on individual patient characteristics.
Expanding Treatment Options for Cancer Patients
This research provides valuable insights into the use of rucaparib in patients with hepatic impairment. The study's findings suggest that rucaparib can be a viable treatment option for individuals with liver dysfunction, expanding the range of available therapies for cancer patients with this common comorbidity. The study emphasizes the need for ongoing research to further investigate the use of rucaparib in patients with hepatic impairment and to optimize treatment strategies for this patient population.
Dr.Camel's Conclusion
Just like a camel can endure the harsh desert climate, rucaparib may be able to withstand the challenges of hepatic impairment. This research provides valuable insights into the safety and effectiveness of rucaparib in patients with liver dysfunction, offering a potential treatment option for those facing this challenging condition. The study reminds us that even in the face of complex medical conditions, like hepatic impairment, we can find solutions and offer hope to those facing the challenges of cancer.
Date :
- Date Completed 2021-09-17
- Date Revised 2023-11-07
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.