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Pooled Safety Results Through 1 Year of 2 Phase III Trials of Guselkumab in Patients With Psoriatic Arthritis.
Author: AgarwalPrasheen, BoehnckeWolf-Henning, GottliebAlice B, HelliwellPhilip S, HsiaElizabeth C, KafkaShelly, KollmeierAlexa P, McInnesIain B, MeasePhilip J, RahmanProton, RamachandranParaneedharan, RitchlinChristopher T, ShawiMay, ShengShihong, XuXie L, ZhouBei, ZhuangYanli
Original Abstract of the Article :
OBJECTIVE: Evaluate the safety of guselkumab (monoclonal antibody targeting interleukin [IL]-23p19) in patients with psoriatic arthritis (PsA) through 1 year (1Y) of the phase III DISCOVER-1 and DISCOVER-2 trials. METHODS: Patients with active PsA (n = 1120; biologic-naïve except 118 patients treat...See full text at original site
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引用元:
https://doi.org/10.3899/jrheum.201532
データ提供:米国国立医学図書館(NLM)
Guselkumab: A Safe Passage Through the Desert of Psoriatic Arthritis
Psoriatic arthritis (PsA), like a relentless desert storm, can cause pain, inflammation, and joint damage, significantly impacting quality of life. This research explores the safety profile of guselkumab, a monoclonal antibody targeting interleukin (IL)-23p19, in patients with PsA. The authors, like explorers navigating the treacherous terrain of autoimmune diseases, analyze data from two phase III clinical trials to assess the safety of guselkumab over a one-year period.
Guselkumab: A Safe Oasis in the Desert of Psoriatic Arthritis
This study, like a desert oasis providing respite from the scorching sun, offers reassurance regarding the safety of guselkumab in PsA patients. The analysis revealed that guselkumab was well-tolerated, with no significant new safety concerns observed. The authors, like meticulous cartographers, detail the safety profile of guselkumab, highlighting its low rates of serious adverse events and specific observations regarding injection-site reactions, antibody development, and changes in serum hepatic transaminase levels and neutrophil counts. These findings, like a clear map guiding us through the complexities of PsA treatment, provide valuable information for clinicians and patients alike.
Navigating the Desert of Autoimmune Diseases
This study, like a beacon in the desert of autoimmune diseases, sheds light on the safety and efficacy of guselkumab in the treatment of PsA. The authors, like astute desert guides, carefully navigate the complex landscape of clinical trials, providing valuable information for patients and clinicians seeking safe and effective treatments. This research, like a well-stocked oasis, offers hope for a brighter future in the treatment of PsA, offering patients a better chance to navigate the challenges of this debilitating condition.
Dr.Camel's Conclusion
This study, like a refreshing spring in the desert of autoimmune diseases, provides valuable insights into the safety of guselkumab in patients with PsA. The authors, like seasoned desert guides, carefully navigate the complexities of clinical trials, offering valuable information for patients and clinicians. These findings offer hope for a brighter future in the treatment of PsA, offering patients a better chance to navigate the challenges of this debilitating condition.
Date :
- Date Completed 2022-01-31
- Date Revised 2022-01-31
Further Info :
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