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Vorinostat exhibits anticancer effects in triple-negative breast cancer cells by preventing nitric oxide-driven histone deacetylation.

Author: BoveeRhea, HickokJason R, KuschmanHannah Petraitis, PalczewskiMarianne B, ThomasDouglas D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of nitric oxide (NO) on the proliferation of triple-negative breast cancer (TNBC) cells and evaluated the potential therapeutic benefit of Vorinostat (SAHA) in counteracting NO-induced tumor growth. SAHA effectively prevented NO-mediated proliferation of TNBC cells by increasing histone acetylation. This finding suggests that SAHA may be a promising therapeutic strategy for aggressive TNBCs that produce NO.
Paper Details　
Original Abstract of the Article :
Triple-negative breast cancers (TNBC) that produce nitric oxide (NO) are more aggressive, and the expression of the inducible form of nitric oxide synthase (NOS2) is a negative prognostic indicator. In these studies, we set out to investigate potential therapeutic strategies to counter the tumor-per...See full text at original site
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引用元：
https://doi.org/10.1515/hsz-2020-0323

データ提供：米国国立医学図書館（NLM）

Vorinostat: A Potential Oasis in the Desert of Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC), a particularly aggressive form of cancer, is like a harsh desert landscape, challenging conventional treatment approaches. This research explores the potential of Vorinostat, a histone deacetylase inhibitor, as a therapeutic strategy for TNBC, seeking to find a path to remission amidst the challenging terrain.

Unveiling the Potential of Vorinostat

This study, like a desert explorer uncovering hidden springs, delves into the molecular mechanisms underlying TNBC and the potential therapeutic role of Vorinostat. The researchers discovered that Vorinostat can effectively inhibit the growth of TNBC cells by counteracting the tumor-promoting effects of nitric oxide (NO). Vorinostat, like a life-giving oasis in the desert, can offer a potential pathway to combatting the aggressive nature of TNBC.

A New Hope for Treatment

This study opens up new avenues for exploring the therapeutic potential of Vorinostat in TNBC. By targeting the specific mechanisms that drive tumor growth, Vorinostat offers a glimmer of hope for patients facing this challenging disease. This research serves as a reminder that persistent exploration and innovative approaches are crucial for navigating the challenging desert landscape of cancer treatment.

Dr.Camel's Conclusion

This research offers a promising new avenue for exploring the treatment of triple-negative breast cancer. Vorinostat, like a refreshing oasis in the desert of cancer, holds potential for effectively combating this aggressive disease. This study underscores the importance of ongoing research and innovation in finding new weapons in the fight against cancer, paving the way for a more hopeful future for patients.

Date :
  1. Date Completed 2021-08-31
  2. Date Revised 2021-08-31
Further Info :

Pubmed ID

33938179

DOI: Digital Object Identifier

10.1515/hsz-2020-0323

Related Literature

Article Analysis
・Effects of vorinostat
SNS
PICO Info
in preparation
Languages

English

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