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Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19.

Author: AfxentiSotiroula, BourdakouMarilena M, ChristodoulouChristiana C, ChristodoulouChristina G, DietisNikolas, KakouriAndrea C, KaratzasEvangelos, KoliosGeorge, KyprianouTheodoros, LoizidouEleni M, MinadakisGeorge, OnisiforouAnna, OulasAnastasis, RichterJan, SavvaKyriaki, SpyrouGeorge M, TomazouMarios, ZachariouMargarita, ZantiMaria

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the potential for drug repurposing in treating COVID-19 by analyzing multi-omic data and identifying drugs targeting genes involved in COVID-19 pathophysiology. It highlighted several promising candidates, including Src tyrosine kinase inhibitors, immunomodulators, and anti-inflammatory drugs.
Paper Details　
Original Abstract of the Article :
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is undeniably the most severe global health emergency since the 1918 Influenza outbreak. Depending on its evolutionary trajectory, the virus is expected to establish itself as an endemic infectious respiratory disease exhibiti...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8135326/

データ提供：米国国立医学図書館（NLM）

Multi-omics Data Integration for Drug Repurposing Against COVID-19

This research showcases a novel approach to [drug repurposing] for [COVID-19] treatment, leveraging the power of [multi-omics data integration] and [network-based analysis]. The authors meticulously analyzed a vast dataset of [multi-omic data], including [patient data], [cell line data], and [databases], to identify potential [drug targets] and prioritize candidate drugs for repurposing. The findings reveal a shortlist of potential [drug candidates] that could be effective against [COVID-19], offering a promising avenue for developing new treatment options.

A Multifaceted Approach to COVID-19 Drug Discovery

The study's findings underscore the power of [multi-omics data integration] in [drug repurposing] research. By leveraging the vast information contained in [multi-omic datasets], researchers can gain a comprehensive understanding of disease mechanisms and identify potential drug targets. This approach could accelerate the development of new treatments for [COVID-19] and other diseases, offering hope for patients and advancing the field of [drug discovery].

Harnessing the Power of Data in Medical Research

This research highlights the transformative potential of [data integration] in medical research. By utilizing [multi-omics data] and [network-based analysis], researchers can gain unprecedented insights into disease processes, identify potential drug targets, and accelerate the development of new treatments. This study demonstrates the importance of leveraging the vast amount of data available to advance medical research and improve patient outcomes.

Dr. Camel's Conclusion

This research showcases a novel and powerful approach to [drug repurposing] for [COVID-19] treatment. The authors' meticulous analysis of [multi-omic data] and [network-based analysis] reveals a shortlist of potential [drug candidates], offering a promising avenue for developing new treatment options and advancing the field of [drug discovery].

Date :
  1. Date Completed 2021-11-15
  2. Date Revised 2023-11-08
Further Info :

Pubmed ID

34009288

DOI: Digital Object Identifier

PMC8135326

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Languages

English

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