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Development of allergic conjunctivitis induced by <i>Acanthamoeba</i> excretory-secretory protein and the effect of resolvin D1 on treatment.

Author: KangMin Seung, LeeJi-Eun, LeeJongsoo, ParkSung Hee, YuHak Sun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that exposure to dust mite allergen (ESP) induced allergic conjunctivitis in both human conjunctival epithelial cells and mice. Treatment with resolvin D1 (RvD1) and antiallergic agents significantly reduced the inflammation.
Paper Details　
Original Abstract of the Article :
PURPOSE: To evaluate whether allergic conjunctivitis (AC) could be induced by METHODS: Human conjunctival epithelial cells (HCVCs) were treated with 10 µg/well of ESP, and Th2 cytokines were measured using real-time PCR. C57BL/6 mice were treated with 10 µg/5 µL of ESP after sensitization, and con...See full text at original site
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引用元：
https://doi.org/10.1080/02713683.2021.1934878

データ提供：米国国立医学図書館（NLM）

Acanthamoeba: A Trigger for Allergic Conjunctivitis

Allergic conjunctivitis, a common eye condition characterized by itchy, watery eyes, can be a real nuisance. This study explores the potential role of Acanthamoeba, a common amoeba found in water and soil, in triggering allergic conjunctivitis.

The study investigated the effects of Acanthamoeba excretory-secretory protein (ESP) on human conjunctival epithelial cells and mice. The results showed that ESP induced the production of Th2 cytokines, suggesting a potential link between Acanthamoeba and allergic conjunctivitis. The study also evaluated the effectiveness of resolvin D1 (RvD1) and antiallergic agents in treating Acanthamoeba-induced allergic conjunctivitis.

A New Perspective on Allergic Conjunctivitis: The Role of Acanthamoeba

This research sheds light on the potential role of Acanthamoeba in triggering allergic conjunctivitis. The study's findings suggest that Acanthamoeba ESP might be a contributing factor in the development of this condition.

Navigating the Desert of Eye Allergies: Understanding Potential Triggers

This research highlights the importance of understanding potential triggers for allergic conjunctivitis. The study's findings suggest that Acanthamoeba could be a potential trigger for this condition, encouraging further investigation into the role of this amoeba in eye allergies.

Dr.Camel's Conclusion

This research takes us on a journey through the desert of eye allergies, exploring the potential role of Acanthamoeba in triggering allergic conjunctivitis. The study's findings offer a new perspective on this common condition, suggesting that Acanthamoeba might be a hidden player in the development of eye allergies. It's a reminder that the desert of health is filled with intricate interactions, and understanding these interactions is crucial for developing effective treatments.

Date :
  1. Date Completed 2022-03-03
  2. Date Revised 2022-03-03
Further Info :

Pubmed ID

34029500

DOI: Digital Object Identifier

10.1080/02713683.2021.1934878

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Languages

English

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