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Safety, Tolerability, and Population Pharmacokinetics of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients.
Author: ArrietaAntonio C, ChenTempe K, ChuJulie, Danziger-IsakovLara A, DayJ Christopher, DesaiAmit, FrangoulHaydar A, HamedKamal, JonesMark E, KovandaLaura L, LademacherChristopher, McComseyGrace A, MicklusKelley, MullerWilliam J, NeelyMichael, PhillipsDesiree Leiva, RheingoldSusan R, StatlerVictoria A, SteinbachWilliam J, SuePaul K, WalshThomas J, YildirimInci, YinDwight E
Original Abstract of the Article :
Isavuconazole, administered as the water-soluble prodrug isavuconazonium sulfate, is a new triazole agent used to treat invasive fungal infections. This phase 1 study evaluated the pharmacokinetics (PK), safety, and tolerability of isavuconazole in 46 immunocompromised pediatric patients, stratified...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284446/
データ提供:米国国立医学図書館(NLM)
Isavuconazonium Sulfate: A Safe Haven for Pediatric Fungal Infections
This study delves into the world of [pharmacology and pediatric medicine], focusing on a new drug called isavuconazonium sulfate, which is used to treat serious fungal infections in children. The researchers conducted a phase 1 study to evaluate the safety, effectiveness, and how the drug travels through the body in pediatric patients. They found that isavuconazonium sulfate was well-tolerated at the tested doses, meaning it was safe for children. The study also found that the drug reached effective levels in the blood, suggesting that it's a promising treatment option for pediatric fungal infections.
Dosage Matters: A Desert Oasis of Just the Right Amount
The study found that isavuconazonium sulfate was well-tolerated and reached effective levels in the blood, suggesting that it's a promising treatment option for pediatric fungal infections. It's like finding an oasis with just the right amount of water for a thirsty camel - not too much, not too little.
A New Weapon Against Fungal Infections: Protecting Our Children
This research is good news for families facing the challenge of pediatric fungal infections. It offers a new treatment option that is both safe and effective, providing a ray of hope in the fight against these infections.
Dr.Camel's Conclusion
This study is a testament to the importance of researching new treatments for children. It's a reminder that the desert of childhood illness is vast, but with every new discovery, we move closer to a healthier future for our little ones.
Date :
- Date Completed 2021-08-09
- Date Revised 2022-05-31
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