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Increased Thyroid-Hormone Requirements Consistent With Type 3 Deiodinase Induction Related to Ibrutinib in a Thyroidectomized Woman.

Author: MazoriAlon Yehuda, SkamagasMaria

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

This case report links the tyrosine kinase inhibitor (TKI) ibrutinib to increased thyroid hormone requirements in a thyroidectomized woman. The patient's decreased T3:T4, T3:rT3, and T4:rT3 ratios suggested type 3 deiodinase induction and type 2 deiodinase inhibition.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Tyrosine-kinase inhibitors (TKIs) are chemotherapeutic agents associated with increased thyroid-hormone requirements and altered deiodinase activity. We present the first case to link these findings to the TKI ibrutinib. METHODS: Serial thyroid-stimulating hormone (TSH), free-thyroxine (...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053622/

データ提供：米国国立医学図書館（NLM）

Ibrutinib and Thyroid-Hormone Requirements: A Case Study

This case study explores the potential impact of the tyrosine-kinase inhibitor (TKI) ibrutinib on thyroid hormone requirements. The study presents a case of a thyroidectomized woman who experienced increased thyroid hormone requirements after starting ibrutinib treatment. The study suggests that ibrutinib may induce type 3 deiodinase, an enzyme involved in thyroid hormone metabolism, leading to altered thyroid hormone levels and increased requirements.

Ibrutinib: A Shifting Oasis in the Desert of Thyroid Hormone Regulation

This case study takes us on a journey through the complex desert of thyroid hormone regulation. It showcases the potential impact of the TKI ibrutinib on thyroid hormone metabolism, highlighting the need for careful monitoring and adjustments in patients receiving this treatment. The case illustrates the delicate balance of thyroid hormones and the importance of understanding the nuances of drug interactions.

Navigating the Desert of Thyroid Disease

This study reminds us of the importance of consulting with a healthcare professional to manage any changes in thyroid hormone levels, particularly when taking medications that may interact with thyroid hormone metabolism. Monitoring thyroid hormone levels and making necessary adjustments can help ensure the best possible outcomes for patients.

Dr. Camel's Conclusion

This case study provides a valuable insight into the potential impact of ibrutinib on thyroid hormone regulation. It highlights the importance of careful monitoring and prompt adjustments to ensure the optimal balance of thyroid hormones in patients receiving this treatment.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-04-23
Further Info :

Pubmed ID

34095468

DOI: Digital Object Identifier

PMC8053622

Related Literature

Article Analysis
・Side Effects of ibrutinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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