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Letermovir in lung transplant recipients with cytomegalovirus infection: A retrospective observational study.

Author: BartonJürgen, BehrJürgen, KaukeTeresa, KepplerOliver T, KneidingerNikolaus, MeiserBruno, MichelSebastian, MilgerKatrin, MunkerDieter, NitschkoHans, VeitTobias, ZollerMichael

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Overview

Letermovir is a new antiviral drug used to treat cytomegalovirus (CMV) infection in transplant recipients. This study examined the effectiveness of letermovir in treating CMV infections that are resistant or unresponsive to other treatments. The study found that letermovir was effective in reducing CMV viral load and resolving infection in most patients. However, some patients developed resistance to letermovir, highlighting the importance of monitoring for drug resistance.
Paper Details　
Original Abstract of the Article :
Letermovir is a new antiviral drug approved for the prophylaxis of CMV infection in allogeneic stem cell transplants. The aim of the study was to assess the therapeutic efficacy of letermovir in difficult to treat CMV infections in lung transplant recipients. All lung transplant recipients between M...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34118118

データ提供：米国国立医学図書館（NLM）

Letermovir: A New Oasis in the Desert of CMV Infections

Cytomegalovirus (CMV) infection can be a formidable challenge, particularly in vulnerable populations like lung transplant recipients. This research investigates the efficacy of letermovir, a new antiviral drug, in treating CMV infections that are resistant to conventional therapies. The study analyzes the effectiveness of letermovir in a retrospective observational study of lung transplant recipients.

Combatting Resistance: A New Weapon in the Arsenal

The study demonstrates that letermovir is effective in treating CMV infections that are resistant to ganciclovir. The authors highlight the rapid response observed in a majority of patients, with significant reduction in CMV viral load. This suggests that letermovir offers a promising new option for managing difficult-to-treat CMV infections in lung transplant recipients, providing a potential oasis of relief in the desert of resistance.

Navigating the Sands of Resistance: A Balancing Act

The authors emphasize the need for careful monitoring for the development of letermovir resistance. The study identifies a potential mutation in the CMV UL56 terminase gene that can confer resistance to letermovir. The authors highlight the importance of early detection and appropriate management of resistance, ensuring that the effectiveness of this promising drug is maintained.

Dr. Camel's Conclusion

This research provides valuable insights into the efficacy of letermovir in treating CMV infections that are resistant to conventional therapies. The study demonstrates the potential of this new antiviral drug to offer a beacon of hope for lung transplant recipients battling CMV infection. While the development of resistance remains a concern, the authors underscore the importance of vigilance and early detection to maximize the effectiveness of this promising treatment option.

Date :
  1. Date Completed 2021-10-18
  2. Date Revised 2023-01-24
Further Info :

Pubmed ID

34118118

DOI: Digital Object Identifier

S1600-6135(22)08764-0

SNS
PICO Info
in preparation
Languages

English

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