IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG).

Author: Bloms-FunkePetra, BoeslIrmgard, CaspaniOmbretta, ChapmanSonya C, Di StefanoGiulia, FinnerupNanna Brix, Garcia-LarreaLuis, GoetzMarcus, KostenkoAnna, MourauxAndré, PelzBernhard, PhillipsKeith G, Pogatzki-ZahnEsther, SchubartKarin, StouffsAlexandre, TraceyIrene, TreedeRolf-Detlef, TroconizIñaki F, TruiniAndrea, Van NielJohannes, VelaJose Miguel, VincentKaty, VollertJan, WanigasekeraVishvarani, WittayerMatthias

Paper Details 
Original Abstract of the Article :
IMI2-PainCare-BioPain-RCT3 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on the nociceptive system that could serve to accelerate the future development of analgesics, by providing a quantitative understanding between drug expos...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212499/

データ提供:米国国立医学図書館(NLM)

Unlocking the Brain's Secrets: Biomarkers for Pain Relief

The search for effective pain relief is a constant pursuit. This study aimed to identify [biomarkers] of pain processing using [electroencephalography (EEG)] to understand how different analgesics affect the brain. The researchers, like skilled neuroscientists exploring the intricate workings of the brain, sought to unlock the secrets of pain perception and develop more effective pain treatments. Their research focuses on the potential of EEG biomarkers to accelerate the development of new analgesics.

EEG Biomarkers: A New Path to Pain Relief

The study aims to identify EEG biomarkers that can track the effects of analgesics on pain processing in the brain. This could lead to a more efficient and targeted approach to developing new pain medications, potentially improving pain relief for patients. Like a skilled cartographer mapping a new territory, the researchers are charting a new path towards understanding and managing pain.

A New Era of Personalized Pain Management

The development of EEG biomarkers for pain processing could usher in a new era of personalized pain management. By understanding how different analgesics affect the brain at an individual level, doctors could tailor treatment strategies to maximize effectiveness and minimize side effects. It’s like discovering a hidden spring in a vast desert - a promising new approach to managing pain that could offer a more personalized and effective solution for patients.

Dr. Camel's Conclusion

This study represents a promising step in the quest for better pain relief. By exploring the potential of EEG biomarkers to understand the brain’s response to analgesics, researchers are paving the way for a more targeted and personalized approach to pain management. It’s like finding a new compass to guide us through the vast desert of pain research - a beacon of hope for a brighter future in pain relief.

Date :
  1. Date Completed 2021-06-21
  2. Date Revised 2021-06-24
Further Info :

Pubmed ID

34140041

DOI: Digital Object Identifier

PMC8212499

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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