Pharmacoepigenomics circuits induced by a novel retinoid-polyamine conjugate in human immortalized keratinocytes.

Author: AnastasakisDimitrios, DrainasDenis, GrafanakiKaterina, KontosChristos K, KorfiatiAigli, KyriakopoulosGeorge, MagoulasGeorge, MavroudiSeferina, PapaioannouDionissios, ScorilasAndreas, SkeparniasIlias, StathopoulosConstantinos, TheofilatosKonstantinos

Paper Details 
Original Abstract of the Article :
Retinoids are widely used in diseases spanning from dermatological lesions to cancer, but exhibit severe adverse effects. A novel all-trans-Retinoic Acid (atRA)-spermine conjugate (termed RASP) has shown previously optimal in vitro and in vivo anti-inflammatory and anticancer efficacy, with undetect...See full text at original site
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引用元:
https://doi.org/10.1038/s41397-021-00241-9

データ提供:米国国立医学図書館(NLM)

Retinoids: A Skin Savior with a Twist

We're always looking for ways to improve our skin health, and retinoids have been a popular choice for treating a variety of skin conditions, from acne to wrinkles. But, like a camel navigating a treacherous desert, retinoids can sometimes have unpleasant side effects. This research delves into the intriguing world of pharmacoepigenomics, focusing on the exciting potential of a new retinoid derivative called RASP. The study employed a strategy similar to a wise traveler carefully selecting their path through a vast desert. Using a combination of miRNA and gene expression analysis, researchers investigated the impact of RASP on human keratinocytes. The findings revealed that RASP, like a gentle oasis in the desert, possesses the beneficial effects of retinoids while minimizing the potential for negative side effects.

RASP: A New Hope for Skin Health

The research demonstrates that RASP is a promising candidate for treating skin disorders, including skin cancer. This is a significant finding, as RASP has shown promising results in its ability to modulate cellular processes involved in skin health. It has the potential to be a game-changer in dermatological treatments.

RASP's Potential Impact on Skin Care

RASP's effectiveness and safety profile suggest that it could become a valuable addition to the skin care toolbox. Think of RASP as a refreshing spring in the desert, offering a new approach to skin care. As this research sheds light on the potential of RASP, we can envision a future where personalized skin care regimens are tailored to individual needs, offering targeted solutions for healthy, glowing skin.

Dr. Camel's Conclusion

This study, like a caravan journeying through the desert, unveils the potential of RASP as a novel retinoid derivative with improved properties, offering a beacon of hope for safer and more effective skin treatments.

Date :
  1. Date Completed 2022-03-10
  2. Date Revised 2023-02-03
Further Info :

Pubmed ID

34145402

DOI: Digital Object Identifier

10.1038/s41397-021-00241-9

Related Literature

SNS
PICO Info
in preparation
Languages

English

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