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The association between cytochrome P450 polymorphisms and anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis.

Author: DengFei, FengJing, JiangFeifei, JiangPeidu, LiuXingren, RenSong, XuDalin, ZhangJingwei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study systematically reviewed and meta-analyzed the relationship between CYP polymorphism and susceptibility to anti-tuberculosis drug-induced liver injury.
Paper Details　
Original Abstract of the Article :
Isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA), and ethambutol (EMB) are the four most common drugs for the first-line treatment of tuberculosis (TB). Although chemotherapy drugs are widely used in the treatment of TB, and achieved good results, but the side effects, especially anti-tuberculo...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/34154362

データ提供：米国国立医学図書館（NLM）

The Association Between Cytochrome P450 Polymorphisms and Anti-Tuberculosis Drug-Induced Liver Injury: A Systematic Review and Meta-Analysis

This comprehensive study investigates the association between genetic variations in cytochrome P450 (CYP) enzymes and the risk of anti-tuberculosis drug-induced liver injury (ATDILI). It's like exploring the vast desert landscape, searching for clues about how certain genetic variations might make individuals more vulnerable to the adverse effects of anti-tuberculosis drugs. The researchers conducted a systematic review and meta-analysis of existing studies, pooling data to assess the strength of the association. Their analysis revealed a complex interplay between CYP polymorphisms and the risk of ATDILI, suggesting that certain genetic variations might influence an individual's susceptibility to liver injury caused by these drugs.

Understanding Genetic Susceptibility: A Key to Personalized Medicine

This study underscores the importance of understanding genetic factors in predicting and managing the risks associated with anti-tuberculosis drug treatment. This is like discovering a hidden map that guides researchers towards a personalized approach to medicine, tailoring treatment strategies based on individual genetic profiles.

Preventing Liver Injury: The Importance of Genetic Screening

The findings highlight the need for further research and development of genetic screening tools to identify individuals at higher risk of ATDILI. This is like having a skilled desert scout who can identify potential hazards and navigate the path to safety.

Dr. Camel's Conclusion

This research takes us on a fascinating journey through the complex world of pharmacogenetics, revealing the intricate connection between genetic variations and drug responses. It emphasizes the importance of individualized medicine, where treatment strategies are tailored to each patient's unique genetic profile. This is like finding a hidden oasis of knowledge in the vast desert of human health, providing valuable insights into the interplay between genes and disease.

Date :
  1. Date Completed 2021-07-12
  2. Date Revised 2021-07-12
Further Info :

Pubmed ID

34154362

DOI: Digital Object Identifier

apm-21-1224

SNS
PICO Info
in preparation
Languages

English

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