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Polydatin Reduces Cardiotoxicity and Enhances the Anticancer Effects of Sunitinib by Decreasing Pro-Oxidative Stress, Pro-Inflammatory Cytokines, and NLRP3 Inflammasome Expression.

Author: BerrettaMassimiliano, BottiGerardo, BuccoloSimona, CavalcantiErnesta, IovineMartina, MaureaNicola, MontopoliMonica, PacconeAndrea, QuagliarielloVincenzo, TaibiRosaria

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the potential cardioprotective and chemosensitizing effects of polydatin, a compound extracted from Polygonum cuspidatum, during treatment with sunitinib, a multi-targeted tyrosine kinase inhibitor. Polydatin was found to reduce oxidative stress and inflammation, as well as decrease the expression of pro-inflammatory cytokines and chemokines involved in myocardial damage and chemoresistance. The results suggest that polydatin may have potential as a nutraceutical agent in preclinical studies of preventive cardio-oncology.
Paper Details　
Original Abstract of the Article :
Renal cell carcinoma (RCC) represents the main renal tumors and are highly metastatic. Sunitinib, a recently-approved, multi-targeted Tyrosine Kinases Inhibitor (TKi), prolongs survival in patients with metastatic renal cell carcinoma and gastrointestinal stromal tumors, however a dose related cardi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226180/

データ提供：米国国立医学図書館（NLM）

A Double Whammy: Sunitinib for Cancer, But with a Side of Cardiotoxicity

The fight against cancer is a complex and challenging battle, with researchers constantly seeking new and effective treatments. This study explores the potential of polydatin, a natural compound with antioxidant and anti-inflammatory properties, to mitigate the cardiotoxicity associated with sunitinib, a tyrosine kinase inhibitor used in the treatment of renal cell carcinoma. The researchers investigated the effects of polydatin on oxidative stress, inflammation, and NLRP3 inflammasome expression in both cardiomyocytes and renal cancer cells. This study provides valuable insights into the potential of polydatin as a cardioprotective agent and a chemosensitizer, potentially enhancing the efficacy of sunitinib while reducing its associated heart risks.

Protecting the Heart While Fighting Cancer

This study highlights the potential of polydatin to protect the heart while enhancing the anticancer effects of sunitinib. By reducing oxidative stress, inflammation, and NLRP3 inflammasome expression, polydatin could mitigate the cardiotoxicity associated with sunitinib, potentially improving patient outcomes.

The Promise of Natural Compounds in Cancer Therapy

This study underscores the potential of natural compounds, such as polydatin, as adjunctive therapies in cancer treatment. The use of natural agents to mitigate the side effects of conventional therapies could improve patient tolerance and enhance overall treatment effectiveness.

Dr.Camel's Conclusion

Imagine a desert traveler facing a harsh sun and dangerous scorpions. This study is like discovering a powerful herb that can protect the traveler from the scorpions' venom while providing a boost of energy. Polydatin, a natural compound, could play a similar role in cancer treatment, protecting the heart from sunitinib's adverse effects while amplifying the drug's cancer-fighting abilities.

Date :
  1. Date Completed n.d.
  2. Date Revised 2021-06-29
Further Info :

Pubmed ID

34178667

DOI: Digital Object Identifier

PMC8226180

Related Literature

Article Analysis
・Effects of sunitinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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