Effects of bortezomib on mouse preimplantation embryo development in vitro.

Author: CobanCennet Sinem, MutluayDuygu

Paper Details 
Original Abstract of the Article :
Bortezomib, a selective inhibitor of 26S proteasome, is commonly used as a chemotherapeutic agent against different types of human cancer cells. While cancer during pregnancy is a rare condition, the trends in becoming pregnant at an advanced age increase the risk of cancer associated with pregnancy...See full text at original site
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引用元:
https://doi.org/10.1002/bdr2.1939

データ提供:米国国立医学図書館(NLM)

Bortezomib: A Balancing Act for Cancer Treatment and Pregnancy

The field of [reproductive toxicology] investigates the potential effects of drugs and environmental factors on the developing embryo and fetus. This study explores the impact of bortezomib, a proteasome inhibitor used in cancer treatment, on mouse preimplantation embryo development. The authors conducted [in vitro experiments] to examine the effects of bortezomib on embryo viability, morphology, and developmental progression.

A Careful Journey: Bortezomib and Embryonic Development

The study reveals that bortezomib exposure during preimplantation development can have detrimental effects on mouse embryos. The authors observed a significant decrease in embryo viability and developmental progression at certain concentrations of bortezomib. These findings highlight the potential risks associated with bortezomib exposure during early pregnancy and underscore the need for careful consideration of its use in women of reproductive age.

Navigating the Sands: Balancing Cancer Treatment and Pregnancy

This study emphasizes the importance of balancing the benefits of cancer treatment with the potential risks to the developing embryo. It underscores the need for careful risk assessment and management strategies when considering bortezomib use during pregnancy. Further research is needed to understand the long-term effects of bortezomib on embryonic development and to develop alternative treatment strategies that minimize potential risks.

Dr.Camel's Conclusion

Just as a camel navigates a desert landscape, balancing the needs of a mother and her developing fetus requires careful consideration. This study highlights the potential risks associated with bortezomib during pregnancy, urging clinicians to approach this situation with caution and prioritize the well-being of both mother and child. As we continue to explore the complexities of cancer treatment during pregnancy, we can work towards a future where mothers can receive effective treatment without compromising their reproductive health.

Date :
  1. Date Completed 2021-11-01
  2. Date Revised 2021-11-01
Further Info :

Pubmed ID

34223698

DOI: Digital Object Identifier

10.1002/bdr2.1939

Related Literature

SNS
PICO Info
in preparation
Languages

English

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