Paper Details

  1. Home
  2. Paper Details

Effect of Esketamine Nasal Spray on Olfactory Function and Nasal Tolerability in Patients with Treatment-Resistant Depression: Results from Four Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Studies.

Author: CooperKim, DalyElla, DotyRichard L, DrevetsWayne C, FedgchinMaggie, JamiesonCarol, JanikAdam, LaneRosanne, LimPilar, MelkoteRama, Ochs-RossRachel, PopovaVanina, SinghJaskaran, WylieCrystal

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Esketamine nasal spray, used in combination with oral antidepressants, did not adversely affect olfactory function or nasal health in patients with treatment-resistant depression. In four clinical studies, 1142 patients received either esketamine or placebo nasal spray for short-term (4 weeks) or long-term (16-100 weeks) treatment. No significant differences were found in olfactory function or nasal health measures between the groups.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Intranasal drug delivery offers a non-invasive and convenient dosing option for patients and physicians, especially for conditions requiring chronic/repeated-treatment administration. However, in some cases such delivery may be harmful to nasal and olfactory epithelia. OBJECTIVE: The ai...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310483/

データ提供：米国国立医学図書館（NLM）

Esketamine Nasal Spray: Impact on Olfactory Function and Nasal Tolerability

The field of [treatment-resistant depression (TRD)] is constantly seeking new and effective treatment options. This study delves into the potential impact of [esketamine nasal spray], a novel treatment for TRD, on [olfactory function] and [nasal tolerability]. Researchers conducted four [multicenter, randomized, double-blind, placebo-controlled, phase III studies] involving 1,142 patients with TRD. Their analysis revealed no evidence of adverse effects on either olfactory function or nasal health, even with long-term intermittent administration. It's like finding a new way to quench your thirst in the desert - esketamine nasal spray offers a potential solution for TRD without causing harm to sensitive nasal tissues.

Esketamine Nasal Spray: Safe and Well-Tolerated

The study's findings provide reassuring evidence that esketamine nasal spray is safe and well-tolerated, with no significant impact on olfactory function or nasal health. This is a significant finding, as it suggests that esketamine nasal spray can be a viable treatment option for TRD without causing unwanted side effects. It's like finding a cool, refreshing oasis in the middle of a scorching desert - a welcome relief without any negative consequences.

A Promising Future for Esketamine Nasal Spray

This research offers hope for patients with TRD, who often struggle to find effective treatments. The safety and tolerability of esketamine nasal spray, along with its potential efficacy, make it a promising new treatment option. As a wise camel, I always say, it's essential to keep exploring new avenues, especially when seeking solutions to challenging problems.

Dr.Camel's Conclusion

This comprehensive study provides evidence that esketamine nasal spray is safe and well-tolerated, with no significant impact on olfactory function or nasal health. These findings support the use of esketamine nasal spray as a potential treatment option for treatment-resistant depression.

Date :
  1. Date Completed 2022-01-31
  2. Date Revised 2022-01-31
Further Info :

Pubmed ID

34235612

DOI: Digital Object Identifier

PMC8310483

Related Literature

Article Analysis
・Effects of esketamine nasal spray
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.